Diaconiţă G
Morphol Embryol (Bucur). 1975;21(4):277-82.
A pathomorphologic study was carried out by the conventional histologic methods in 193 cases of pleomorphous macrocellular pulmonary carcinoma, of a total of 1,637 cases of lung cancer diagnosed histologically between January 1, 1961 and December 31, 1974. In comparison to other histologic types, the incidence of macrocellular carcinomas was of 11.8%, 62.6% belonged to the 40-60 years age-group, with male predominance. The results showed this carcinoma to be an autonomous type of neoplastic proliferation. The pathomorphologic particularities observed in the 193 cases and their evolution are conclusive arguments for considering pleomorphous macrocellular carcinomas as a separate histologic type in the classification of lung cancers. The term of pleomorphous macrocellular carcinoma appears to be the most comprehensive and in keeping with the histologic structure of these tumours. Cellular pleomorphism is an important diagnostic feature. Zones of specific differentiation observed in some cases may be included in the pleomorphism of these carcinomas. Notions of histogenesis are likewise discussed. It is increasingly assumed that these carcinomas are morphologically the expression of a cellular proliferation, differentiation and maturization response to the action of complex factors. The reduced stroma of these carcinomas indicate a more rapid increase of the tumoural parenchyma.
1961年1月1日至1974年12月31日期间，在1637例经组织学诊断的肺癌患者中，采用传统组织学方法对193例多形性大细胞肺癌进行了病理形态学研究。与其他组织学类型相比，大细胞癌的发病率为11.8%，62.6%属于40 - 60岁年龄组，男性居多。结果显示，这种癌是一种自主性肿瘤增殖类型。在这193例病例中观察到的病理形态学特征及其演变，是将多形性大细胞癌视为肺癌分类中一种独立组织学类型的确凿依据。多形性大细胞癌这一术语似乎最为全面，且与这些肿瘤的组织结构相符。细胞多形性是一项重要的诊断特征。在某些病例中观察到的特异性分化区域可能包含在这些癌的多形性之中。同样也讨论了组织发生学的概念。越来越多的人认为，这些癌在形态学上是对复杂因素作用的细胞增殖、分化和成熟反应的表现。这些癌的间质减少表明肿瘤实质增长更快。
