ΔF508囊性纤维化突变与肠套叠无关：对轮状病毒疫苗的启示。
Delta-F508 cystic fibrosis mutation is not linked to intussusception: implications for rotavirus vaccine.
作者信息
Barnes G, Srivastava A, Carlin J, Francis I
机构信息
The Murdoch Childrens Research Institute, University of Melbourne, Royal Children's Hospital, Parkville, Australia.
出版信息
J Paediatr Child Health. 2003 Sep-Oct;39(7):516-7. doi: 10.1046/j.1440-1754.2003.00204.x.
OBJECTIVE
To determine whether the cystic fibrosis (CF) delta-F508 gene mutation predisposes to intussusception, and so selects infants who should not receive rotavirus vaccine.
METHODS
Stored neonatal screening blood spots, retrieved from 81 infants with intussusception and from 79 controls, were tested for the presence of the CF delta-F508 gene mutation.
RESULTS
Prevalence of the mutation was similar in blood specimens from intussusception patients and from controls.
CONCLUSION
Testing for the CF delta-F508 mutation at birth is unlikely to identify infants predisposed to intussusception, and therefore is not relevant to rotavirus vaccine programs.
目的
确定囊性纤维化（CF）Δ-F508基因突变是否易导致肠套叠，从而筛选出不应接种轮状病毒疫苗的婴儿。
方法
对从81例肠套叠婴儿和79例对照中获取的储存新生儿筛查血斑进行CF Δ-F508基因突变检测。
结果
肠套叠患者和对照的血标本中该突变的发生率相似。
结论
出生时检测CF Δ-F508突变不太可能识别出易患肠套叠的婴儿，因此与轮状病毒疫苗计划无关。
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