Tan Sardjono Caroline, Mottram Patricia L, Hogarth P Mark
Austin Research Institute, Kronheimer Building, Austin and Repatriation Medical Centre, Melbourne, Australia.
Immunol Cell Biol. 2003 Oct;81(5):374-81. doi: 10.1046/j.1440-1711.2003.01182.x.
Despite their essential role in host protection, immunoglobulins are also involved in autoimmune processes where antibodies recognize the host's own tissue, triggering inflammatory responses that result in extensive tissue damage. A complex interaction of genetic predisposition, together with environment factors, is thought to trigger immune dysfunction. Although recent studies have dissected the essential role of Fc receptors in autoimmune antibody mediated processes, the uniquely human FcgammaRIIa has not been studied in detail. This Fc receptor is of particular interest, as it is the most abundantly expressed Fc receptor in humans and is implicated in immune complex disease. Investigation of its role has been hampered to date due to lack of suitable animal models. This review examines the evidence for the direct role of this receptor in diseases such as systemic lupus erythematosus and rheumatoid arthritis.
尽管免疫球蛋白在宿主保护中发挥着重要作用，但它们也参与自身免疫过程，即抗体识别宿主自身组织，引发炎症反应，导致广泛的组织损伤。遗传易感性与环境因素的复杂相互作用被认为会引发免疫功能障碍。尽管最近的研究剖析了Fc受体在自身免疫抗体介导过程中的重要作用，但人类特有的FcγRIIa尚未得到详细研究。这种Fc受体特别引人关注，因为它是人类中表达最丰富的Fc受体，并且与免疫复合物疾病有关。由于缺乏合适的动物模型，迄今为止对其作用的研究受到了阻碍。这篇综述探讨了该受体在系统性红斑狼疮和类风湿性关节炎等疾病中直接作用的证据。
