类风湿关节炎和系统性红斑狼疮患者血清中的IgG Fc受体

IgG Fc receptors in sera from patients with rheumatoid arthritis and systemic lupus erythematosus.

作者信息

Ulvestad E, Matre R, Tønder O

机构信息

Broegelmann Research Laboratory for Microbiology, Bergen, Norway.

出版信息

Scand J Rheumatol Suppl. 1988;75:203-8. doi: 10.3109/03009748809096763.

DOI:10.3109/03009748809096763

PMID:3238352

Abstract

A murine monoclonal antibody to receptors for IgG (FcR) in human placenta was used in a competitive ELISA to demonstrate soluble FcR in human sera. Sera from 20 blood donors, 30 patients with systemic lupus erythematosus and 50 patients with rheumatoid arthritis were examined. Soluble FcR were demonstrated in all sera. However, significantly lower amounts of FcR were demonstrated in the patient groups as compared to blood donors. Whether this is due to increased consumption or reduced production has to be further investigated. The findings may be of significance in the pathogenesis of these diseases.

摘要

一种针对人胎盘IgG受体（FcR）的鼠单克隆抗体被用于竞争性酶联免疫吸附测定（ELISA），以检测人血清中的可溶性FcR。检测了20名献血者、30名系统性红斑狼疮患者和50名类风湿性关节炎患者的血清。所有血清中均检测到可溶性FcR。然而，与献血者相比，患者组中FcR的含量明显较低。这是由于消耗增加还是产生减少，还有待进一步研究。这些发现可能对这些疾病的发病机制具有重要意义。