Clinical Research Division, Department of Medical Research, Rangoon, Myanmar, Burma.
J Diarrhoeal Dis Res. 1992 Dec;10(4):201-4.
We have determined the effects of berberine (Berberis aristita) on intestinal fluid accumulation due to enterotoxigenic E. coli (ETEC) heat-stable (ST) toxin in suckling (24-days old) Wistar rats. Intestinal fluid accumulation occurred in suckling Wistar rats by administration of culture filtrate containing ST-producing ETEC in serial dilutions up to 1/8 dilution by oral or intragastric route. When berberine (0.1 mg) and 1/8 dilution of ST-toxin were given together by oral or intragastric injection, a significant (p < 0.01) reduction in fluid accumulation was observed. Neither treatment with berberine orally before intragastric injection of ST-toxin nor intragastric administration of berberine after ST-toxin reduced the fluid accumulation due to ST-toxin.
我们已经确定了黄连素（小檗）对24日龄哺乳Wistar大鼠因产肠毒素大肠杆菌（ETEC）热稳定（ST）毒素引起的肠液积聚的影响。通过口服或胃内途径给予含产ST的ETEC培养滤液的系列稀释液直至1/8稀释液，哺乳Wistar大鼠会出现肠液积聚。当通过口服或胃内注射同时给予黄连素（0.1毫克）和1/8稀释的ST毒素时，观察到液体积聚显著减少（p < 0.01）。在胃内注射ST毒素前口服黄连素或在ST毒素后胃内给予黄连素均未减少因ST毒素引起的液体积聚。
