Wise C M, Knight A P, Lucas M J, Morris C J, Ellis R P, Phillips R W
Am J Vet Res. 1983 Dec;44(12):2221-5.
The inhibitory effect of salicylates on intestinal secretion in 1- to 5-day-old calves given Escherichia coli heat-stable enterotoxin (ST)-induced intestinal fluid response was investigated. Purified ST was diluted in isotonic saline solution to obtain 1:10, 1:25, 1:50, 1:75, and 1:100 dilutions. Each dilution (1 ml) was inoculated into ligated loops in the distal part of the jejunum of each calf. Acetylsalicylic acid (aspirin) given orally (100 mg/kg) at 4 hours before ST was inoculated did not substantially alter the intestinal fluid response to ST. Sodium salicylate (IV) infusion, begun simultaneously when, or at 1 hour after, ST was inoculated, significantly (P less than 0.05) decreased fluid accumulation in those loops inoculated with ST dilutions of 1:25 or greater. The sodium and potassium concentrations of the accumulated fluid did not differ significantly between or within treatment groups. These results indicate that sodium salicylate infusion may be beneficial in treating enterotoxic colibacillosis in calves. Aspirin given orally at the dose used in the present study, would not have any beneficial effect.
研究了水杨酸盐对1至5日龄小牛肠道分泌的抑制作用，这些小牛给予大肠杆菌热稳定肠毒素（ST）诱导的肠液反应。将纯化的ST用等渗盐溶液稀释，得到1:10、1:25、1:50、1:75和1:100的稀释液。将每种稀释液（1毫升）接种到每头小牛空肠远端的结扎肠袢中。在接种ST前4小时口服乙酰水杨酸（阿司匹林）（100毫克/千克），对肠道对ST的液体反应没有实质性改变。在接种ST的同时或接种后1小时开始静脉输注水杨酸钠，显著（P小于0.05）减少了接种1:25或更高ST稀释液的肠袢中的液体蓄积。各治疗组之间或组内，蓄积液体的钠和钾浓度没有显著差异。这些结果表明，静脉输注水杨酸钠可能有助于治疗小牛的肠毒性大肠杆菌病。本研究中使用的口服阿司匹林剂量不会产生任何有益效果。
