Bertin A
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1982 Apr;251(4):522-8.
The effect of propranolol pretreatment on fluid accumulation induced in the suckling mouse by heat-stable toxin from Enterotoxigenic Escherichia coli strains of bovine and human origin was studies. The ratio of intestinal weight to body weight is reduced after subcutaneous and per os propranolol treatment when sub-maximal fluid accumulation is induced by diluted crude supernatants of cultures of ETEC reference strain B41. The effect is not dose-dependent above 6.25 m/kg. Propranolol can antagonize fluid accumulation induced by heat stable toxin from reference strain H 10407 at the same doses, although the results are only significant when a higher level of secretion is induced. The results show that, like other pharmacological agents whose action upon intestinal secretion by toxins is still unclear, propranolol can antagonize fluid accumulation induced in the infant mouse by heat-stable toxin.
研究了普萘洛尔预处理对牛源和人源产肠毒素大肠杆菌菌株的热稳定毒素诱导的乳鼠体液积聚的影响。当用产肠毒素大肠杆菌参考菌株B41培养物的稀释粗上清液诱导亚最大体液积聚时，皮下和口服普萘洛尔治疗后肠重与体重之比降低。剂量高于6.25mg/kg时，该作用不呈剂量依赖性。相同剂量下，普萘洛尔可拮抗参考菌株H 10407的热稳定毒素诱导的体液积聚，尽管只有在诱导更高水平的分泌时结果才具有显著性。结果表明，与其他对毒素引起的肠道分泌作用仍不清楚的药物一样，普萘洛尔可拮抗热稳定毒素在幼鼠中诱导的体液积聚。
