Data regarding the restorative effects of the partial removal of the liver in advanced stages of toxic cirrhosis.

The effects of subtotal hepatectomy of albino rats liver cirrhois at 6 and 9 months after the start of CCl4 administration were studied. The results were assessed through self-control and comparison with similar groups in which the spontaneous reversibility of cirrhotic lesions was followed. In the group of 6 months, the liver exeresis results in normalization of morphological and biochemical liver aspects within a period of one month from the intervention. In the group of 9 months, one may also note a stimulation of the regenerative capacity of parenchyma and marked collagenolytic effects without the complete restoration of the stroma/parenchyma ratio. It seems that the major exereses are also effective in the advanced stages of liver cirrosis once the threshold of spontaneous reversibility has been exceeded.