Alborzi Saeed, Motazedian Shahdokht, Parsanezhad Mohammad E, Jannati Sima
Division of Infertility and Endoscopy, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
Fertil Steril. 2003 Sep;80(3):595-9. doi: 10.1016/s0015-0282(03)00980-4.
To compare a single periovulatory intrauterine insemination (IUI) with a regimen based on double IUI, performed during preovulatory and periovulatory periods, in patients undergoing controlled ovarian hyperstimulation (COH).
Prospective, randomized study.
Infertility and endocrinology units of a medical university.
PATIENT(S): One hundred ten patients with male factor, cervical factor, and unexplained infertility who were undergoing 486 cycles of COH with IUI.
INTERVENTION(S): The patients were randomly divided into two groups. One group underwent single IUI in the first cycle and double IUI in the second cycle; this alternating pattern was continued up to six cycles unless pregnancy occurred. For patients in the second group, double IUI was performed in the first cycle and single IUI in the second cycle; this pattern was repeated as in the first group.
MAIN OUTCOME MEASURE(S): Relationship of single and double IUI to rates of clinical pregnancy and abortion.
RESULT(S): Forty-two women became pregnant, with an overall pregnancy rate per cycle of 8.6% and pregnancy rate per couple of 38.2%. Pregnancy rate per cycle was 7.9% in single IUI cycles and was 9.4% in double IUI cycles; these findings were not statistically significant.
CONCLUSION(S): Among patients undergoing COH-IUI, results of single and double IUI do not statistically differ.
比较在接受控制性卵巢刺激（COH）的患者中，单次排卵期宫内人工授精（IUI）与在排卵前和排卵期进行的基于双次IUI方案的效果。
前瞻性随机研究。
一所医科大学的不孕不育与内分泌科。
110例因男方因素、宫颈因素及不明原因不孕而接受486个周期COH并进行IUI的患者。
将患者随机分为两组。一组在第一个周期进行单次IUI，在第二个周期进行双次IUI；这种交替模式持续至六个周期，除非怀孕。第二组患者在第一个周期进行双次IUI，在第二个周期进行单次IUI；模式与第一组相同重复。
单次和双次IUI与临床妊娠率和流产率的关系。
42名女性怀孕，每个周期的总体妊娠率为8.6%，每对夫妇的妊娠率为38.2%。单次IUI周期的每个周期妊娠率为7.9%，双次IUI周期的妊娠率为9.4%；这些结果无统计学差异。
在接受COH-IUI的患者中，单次和双次IUI的结果在统计学上无差异。
