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A mutated progesterone receptor allele is more prevalent in unexplained infertility.

作者信息

Pisarska Margareta D, Carson Sandra A, Casson Peter R, Tong Xiaowen, Buster John E, Kieback Dirk G

出版信息

Fertil Steril. 2003 Sep;80(3):651-3. doi: 10.1016/s0015-0282(03)00755-6.

DOI:10.1016/s0015-0282(03)00755-6
PMID:12969718
Abstract
摘要

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A mutated progesterone receptor allele is more prevalent in unexplained infertility.一种突变的孕酮受体等位基因在不明原因不孕症中更为普遍。
Fertil Steril. 2003 Sep;80(3):651-3. doi: 10.1016/s0015-0282(03)00755-6.
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Polymorphisms in estrogen receptor-α are associated with idiopathic female infertility.雌激素受体-α 多态性与特发性女性不孕有关。
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Generation of a mouse for conditional excision of progesterone receptor.用于条件性切除孕酮受体的小鼠的产生。
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Progesterone receptor gene polymorphism is associated with decreased risk for breast cancer by age 50.孕激素受体基因多态性与50岁前患乳腺癌风险降低相关。
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Combination of polymorphisms in luteinizing hormone β, estrogen receptor β and progesterone receptor and susceptibility to infertility and endometriosis.黄体生成素β、雌激素受体β和孕激素受体多态性与不孕和子宫内膜异位症易感性的关系。
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6
Aberrant activation of canonical Notch1 signaling in the mouse uterus decreases progesterone receptor by hypermethylation and leads to infertility.小鼠子宫中经典Notch1信号通路的异常激活通过高甲基化降低孕激素受体水平并导致不孕。
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[Insulin-like growth factor II and its receptor gene expression in the endometrium of women with unexplained infertility].[胰岛素样生长因子II及其受体基因在不明原因不孕症女性子宫内膜中的表达]
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Isolation of a polymorphic CA repeat sequence at the human progesterone receptor (PGR) locus.人孕激素受体（PGR）基因座上多态性CA重复序列的分离。
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Gender-sensitive association of CFTR gene mutations and 5T allele emerging from a large survey on infertility.一项关于不孕症的大型调查中出现的CFTR基因突变与5T等位基因的性别敏感关联。
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GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice.黄体化过程中GATA4和GATA6基因敲低抑制雌性小鼠黄体中的孕酮生成和促性腺激素反应性。
Biol Reprod. 2015 Dec;93(6):133. doi: 10.1095/biolreprod.115.132969. Epub 2015 Oct 28.

引用本文的文献

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Luteal phase support in assisted reproductive technology.辅助生殖技术中的黄体期支持。
Nat Rev Endocrinol. 2024 Mar;20(3):149-167. doi: 10.1038/s41574-023-00921-5. Epub 2023 Dec 18.
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What Do We Know about Classical and Non-Classical Progesterone Receptors in the Human Female Reproductive Tract? A Review.我们对人类女性生殖道中的经典型和非经典型孕激素受体了解多少？综述。
Int J Mol Sci. 2021 Oct 19;22(20):11278. doi: 10.3390/ijms222011278.
3
MTHFR (C677T) polymorphism and PR (PROGINS) mutation as genetic factors for preterm delivery, fetal death and low birth weight: A Northeast Indian population based study.
MTHFR（C677T）基因多态性和PR（PROGINS）突变作为早产、胎儿死亡及低出生体重的遗传因素：一项基于印度东北部人群的研究
Meta Gene. 2015 Jan 31;3:31-42. doi: 10.1016/j.mgene.2014.12.002. eCollection 2015 Feb.
4
Endometrial gene expression reveals compromised progesterone signaling in women refractory to embryo implantation.子宫内膜基因表达揭示了对胚胎着床难治的女性中孕激素信号传导受损。
Reprod Biol Endocrinol. 2014 Sep 23;12:92. doi: 10.1186/1477-7827-12-92.
5
Polymorphism of genes and implantation failure.基因多态性与植入失败
Int J Mol Cell Med. 2013 Winter;2(1):1-8.
6
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility.原孕激素受体基因多态性与子宫内膜异位症相关不孕或特发性不孕无关。
Clinics (Sao Paulo). 2010;65(11):1073-6. doi: 10.1590/s1807-59322010001100002.
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Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population.孕激素受体多态性与台湾汉族人群特发性复发性流产的相关性研究。
J Assist Reprod Genet. 2011 Mar;28(3):239-43. doi: 10.1007/s10815-010-9510-8. Epub 2010 Nov 18.
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Role of progesterone receptor polymorphisms in the recurrent spontaneous abortions: Indian case.孕激素受体多态性在复发性自然流产中的作用：印度病例。
PLoS One. 2010 Jan 14;5(1):e8712. doi: 10.1371/journal.pone.0008712.
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Control of oocyte release by progesterone receptor-regulated gene expression.通过孕酮受体调节基因表达来控制卵母细胞释放
Nucl Recept Signal. 2009 Dec 31;7:e012. doi: 10.1621/nrs.07012.
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Association of progesterone receptor polymorphisms with recurrent implantation failure after in vitro fertilization and embryo transfer.孕酮受体基因多态性与体外受精-胚胎移植后反复种植失败的相关性
J Assist Reprod Genet. 2008 Apr;25(4):119-22. doi: 10.1007/s10815-008-9210-9.