白细胞计数与心血管危险因素。
Leukocyte count and cardiovascular risk factors.
作者信息
Ingram D D, Gillum R F
机构信息
National Center for Health Statistics, Office of Analysis and Epidemiology, Hyattsville, MD 20782.
出版信息
J Natl Med Assoc. 1992 Dec;84(12):1041-3.
In view of the growing evidence for leukocyte count as an important cardiovascular risk factor, data from the first National Health and Nutrition Examination Survey (NHANES I) were examined to determine the association of leukocyte count with a number of other cardiovascular risk factors. Complete data were available for 5586 persons. Multiple linear regression analyses revealed hemoglobin concentration and height in white male nonsmokers and hemoglobin, cigarettes/day, and pulse rate in white male smokers were associated with leukocyte count. In white female nonsmokers, age, pulse rate, systolic blood pressure, height, and uric acid concentration were associated with leukocyte count. In white female smokers, hemoglobin, cigarettes/day, pulse rate, and height were associated with leukocyte count. However, associated variables explained only 8% of the variation in leukocyte count. Other measured risk factors were not associated with leukocyte count. Future analyses of leukocyte count and cardiovascular disease should control for hemoglobin concentration and pulse rate in addition to smoking, blood pressure, and cholesterol.
鉴于白细胞计数作为重要心血管危险因素的证据越来越多，我们对首次全国健康与营养检查调查（NHANES I）的数据进行了分析，以确定白细胞计数与其他一些心血管危险因素之间的关联。共有5586人的完整数据。多元线性回归分析显示，白人男性非吸烟者的血红蛋白浓度和身高，以及白人男性吸烟者的血红蛋白、每日吸烟量和脉搏率与白细胞计数有关。在白人女性非吸烟者中，年龄、脉搏率、收缩压、身高和尿酸浓度与白细胞计数有关。在白人女性吸烟者中，血红蛋白、每日吸烟量、脉搏率和身高与白细胞计数有关。然而，相关变量仅解释了白细胞计数变异的8%。其他测量的危险因素与白细胞计数无关。未来关于白细胞计数与心血管疾病的分析，除了吸烟、血压和胆固醇外，还应控制血红蛋白浓度和脉搏率。
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