Di Cera Enrico
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA.
Chest. 2003 Sep;124(3 Suppl):11S-7S. doi: 10.1378/chest.124.3_suppl.11s.
After generation from prothrombin, thrombin plays multiple roles in the blood coagulation cascade that are mediated by interaction with a number of physiologic substrates, effectors, and inhibitors. Structural and mutagenesis studies have helped unravel the molecular basis of thrombin interactions in the context of both well-established and emerging new roles of the enzyme. The functional versatility of thrombin owes much to its evolutionary origin and results from structural determinants and mechanisms that can be exploited by pharmacologic intervention.
凝血酶由凝血酶原生成后，在凝血级联反应中发挥多种作用，这些作用是通过与多种生理底物、效应物和抑制剂相互作用介导的。结构研究和诱变研究有助于在该酶既定的和新出现的作用背景下揭示凝血酶相互作用的分子基础。凝血酶的功能多样性很大程度上归因于其进化起源，并且源于可通过药物干预加以利用的结构决定因素和机制。
