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1
The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins.编码单纯疱疹病毒1型潜伏相关转录物的基因会影响编码凋亡调节蛋白的转录物（Bcl-x(L)和Bcl-x(S)）的积累。
J Virol. 2003 Oct;77(19):10714-8. doi: 10.1128/jvi.77.19.10714-10718.2003.
2
Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture.1型单纯疱疹病毒潜伏相关转录本中足以实现野生型自发激活的区域可促进组织培养中的细胞存活。
J Virol. 2001 Apr;75(8):3636-46. doi: 10.1128/JVI.75.8.3636-3646.2001.
3
Identification of two small RNAs within the first 1.5-kb of the herpes simplex virus type 1-encoded latency-associated transcript.在单纯疱疹病毒1型编码的潜伏相关转录本的首个1.5千碱基内鉴定出两种小RNA。
J Neurovirol. 2008 Jan;14(1):41-52. doi: 10.1080/13550280701793957.
4
Regulation of caspase 8- and caspase 9-induced apoptosis by the herpes simplex virus type 1 latency-associated transcript.单纯疱疹病毒1型潜伏相关转录物对caspase 8和caspase 9诱导的细胞凋亡的调控。
J Neurovirol. 2002 Dec;8 Suppl 2:103-11. doi: 10.1080/13550280290101085.
5
The Latency-Associated Transcript Inhibits Apoptosis via Downregulation of Components of the Type I Interferon Pathway during Latent Herpes Simplex Virus 1 Ocular Infection.潜伏相关转录物通过下调Ⅰ型干扰素途径的成分抑制潜伏单纯疱疹病毒 1 眼部感染中的细胞凋亡。
J Virol. 2019 May 1;93(10). doi: 10.1128/JVI.00103-19. Print 2019 May 15.
6
Transgenic mouse with the herpes simplex virus type 1 latency-associated gene: expression and function of the transgene.携带单纯疱疹病毒1型潜伏相关基因的转基因小鼠：转基因的表达与功能
J Virol. 2003 Dec;77(23):12421-9. doi: 10.1128/jvi.77.23.12421-12429.2003.
7
A herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of latency-associated transcript has a wild-type reactivation phenotype in the mouse.一种1型单纯疱疹病毒突变体，其表达杆状病毒凋亡抑制基因以取代潜伏相关转录本，在小鼠中具有野生型再激活表型。
J Virol. 2005 Oct;79(19):12286-95. doi: 10.1128/JVI.79.19.12286-12295.2005.
8
Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latency.单纯疱疹病毒潜伏相关转录本编码一种蛋白质，该蛋白质能极大地增强病毒生长，可弥补即刻早期基因表达的缺陷，并且可能在病毒从潜伏状态重新激活的过程中发挥作用。
J Virol. 1999 Aug;73(8):6618-25. doi: 10.1128/JVI.73.8.6618-6625.1999.
9
A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels.一种能够阻断细胞凋亡的基因可替代1型单纯疱疹病毒潜伏相关转录基因，并恢复野生型再激活水平。
J Virol. 2002 Feb;76(3):1224-35. doi: 10.1128/jvi.76.3.1224-1235.2002.
10
A speculated ribozyme site in the herpes simplex virus type 1 latency-associated transcript gene is not essential for a wild-type reactivation phenotype.在单纯疱疹病毒 1 潜伏相关转录基因中推测的核酶位点对于野生型再激活表型不是必需的。
J Neurovirol. 2008 Nov;14(6):558-62. doi: 10.1080/13550280802275912.

引用本文的文献

1
"Non-Essential" Proteins of HSV-1 with Essential Roles In Vivo: A Comprehensive Review.单纯疱疹病毒 1 中具有重要体内功能的“非必需”蛋白：全面综述。
Viruses. 2020 Dec 23;13(1):17. doi: 10.3390/v13010017.
2
Role of activating transcription factor 3 in the synthesis of latency-associated transcript and maintenance of herpes simplex virus 1 in latent state in ganglia.激活转录因子3在潜伏相关转录本合成及单纯疱疹病毒1于神经节中维持潜伏状态的作用。
Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):E5420-6. doi: 10.1073/pnas.1515369112. Epub 2015 Aug 24.
3
Small non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival.小型非编码 RNA 编码在单纯疱疹病毒 1 潜伏相关转录物（LAT）内，与维甲酸诱导基因 I（RIG-I）合作诱导β-干扰素启动子活性并促进细胞存活。
Virus Res. 2013 Aug;175(2):101-9. doi: 10.1016/j.virusres.2013.04.005. Epub 2013 May 3.
4
Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line.水痘带状疱疹病毒与带状疱疹后神经痛相关，可诱导 ND7-23Nav-1.8 神经母细胞瘤细胞系钠离子电流密度增加。
PLoS One. 2013;8(1):e51570. doi: 10.1371/journal.pone.0051570. Epub 2013 Jan 31.
5
Identification of herpes simplex virus type 1 proteins encoded within the first 1.5 kb of the latency-associated transcript.鉴定潜伏相关转录物 1.5kb 内编码的单纯疱疹病毒 1 蛋白。
J Neurovirol. 2009 Sep;15(5-6):439-48. doi: 10.3109/13550280903296353.
6
Herpes simplex virus type 1 latency-associated transcript inhibits apoptosis and promotes neurite sprouting in neuroblastoma cells following serum starvation by maintaining protein kinase B (AKT) levels.单纯疱疹病毒 1 型潜伏相关转录物通过维持蛋白激酶 B（AKT）水平抑制神经母细胞瘤细胞凋亡并促进血清饥饿后的神经突发芽。
J Gen Virol. 2010 Apr;91(Pt 4):858-66. doi: 10.1099/vir.0.015719-0. Epub 2009 Dec 2.
7
Two small RNAs encoded within the first 1.5 kilobases of the herpes simplex virus type 1 latency-associated transcript can inhibit productive infection and cooperate to inhibit apoptosis.编码于单纯疱疹病毒1型潜伏相关转录本前1.5千碱基内的两个小RNA可抑制 productive感染并协同抑制细胞凋亡。 （注：productive 在此处可能是“有效、 productive性的”意思，但结合语境推测可能是特定医学术语，这里直接保留英文未翻译，因为不确定准确中文释义）
J Virol. 2009 Sep;83(18):9131-9. doi: 10.1128/JVI.00871-09. Epub 2009 Jul 8.
8
Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency.潜伏期间表达的一种新型1型单纯疱疹病毒转录本和蛋白（AL3）的鉴定。
J Gen Virol. 2009 Oct;90(Pt 10):2342-2352. doi: 10.1099/vir.0.013318-0. Epub 2009 Jul 1.
9
Identification of two small RNAs within the first 1.5-kb of the herpes simplex virus type 1-encoded latency-associated transcript.在单纯疱疹病毒1型编码的潜伏相关转录本的首个1.5千碱基内鉴定出两种小RNA。
J Neurovirol. 2008 Jan;14(1):41-52. doi: 10.1080/13550280701793957.
10
A triple entente: virus, neurons, and CD8+ T cells maintain HSV-1 latency.三方协约：病毒、神经元和CD8 + T细胞维持单纯疱疹病毒1型潜伏感染。
Immunol Res. 2006;36(1-3):119-26. doi: 10.1385/IR:36:1:119.

本文引用的文献

1
Regulation of caspase 8- and caspase 9-induced apoptosis by the herpes simplex virus type 1 latency-associated transcript.单纯疱疹病毒1型潜伏相关转录物对caspase 8和caspase 9诱导的细胞凋亡的调控。
J Neurovirol. 2002 Dec;8 Suppl 2:103-11. doi: 10.1080/13550280290101085.
2
Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system.小鼠神经系统发育过程中凋亡调节蛋白Bid、Bcl-2、Bcl-X、Bax和Bak的表达动态
Cell Death Differ. 2002 Feb;9(2):145-57. doi: 10.1038/sj.cdd.4400934.
3
A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels.一种能够阻断细胞凋亡的基因可替代1型单纯疱疹病毒潜伏相关转录基因，并恢复野生型再激活水平。
J Virol. 2002 Feb;76(3):1224-35. doi: 10.1128/jvi.76.3.1224-1235.2002.
4
Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo.单纯疱疹病毒1型潜伏相关转录本中在体外保护细胞免于凋亡并在体内保护神经元细胞的区域。
J Virol. 2002 Jan;76(2):717-29. doi: 10.1128/jvi.76.2.717-729.2002.
5
Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein.在表达Bcl-xL的MCF7-Fas细胞线粒体上半胱天冬酶-8的失活：双功能凋亡调节蛋白的作用
J Biol Chem. 2002 Feb 8;277(6):4351-60. doi: 10.1074/jbc.M108947200. Epub 2001 Dec 3.
6
FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis.FLICE抑制蛋白：死亡受体介导的细胞凋亡调节因子
Mol Cell Biol. 2001 Dec;21(24):8247-54. doi: 10.1128/MCB.21.24.8247-8254.2001.
7
Herpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors.1型单纯疱疹病毒2千碱基潜伏相关转录本内含子与核糖体蛋白和剪接因子相关联。
J Virol. 2001 Dec;75(24):12070-80. doi: 10.1128/JVI.75.24.12070-12080.2001.
8
The expanding role of mitochondria in apoptosis.线粒体在细胞凋亡中不断扩展的作用。
Genes Dev. 2001 Nov 15;15(22):2922-33.
9
Modulation of apoptosis during herpes simplex virus infection in human cells.人类细胞单纯疱疹病毒感染期间细胞凋亡的调控
Microbes Infect. 2001 Aug;3(10):859-66. doi: 10.1016/s1286-4579(01)01444-7.
10
HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas.单纯疱疹病毒和糖蛋白J可抑制颗粒酶B或Fas诱导的半胱天冬酶激活及细胞凋亡。
J Immunol. 2001 Oct 1;167(7):3928-35. doi: 10.4049/jimmunol.167.7.3928.

编码单纯疱疹病毒1型潜伏相关转录物的基因会影响编码凋亡调节蛋白的转录物（Bcl-x(L)和Bcl-x(S)）的积累。

The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins.

作者信息

Peng Weiping, Henderson Gail, Perng Guey-Chuen, Nesburn Anthony B, Wechsler Steven L, Jones Clinton

机构信息

Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska 68583-0905, USA.

出版信息

J Virol. 2003 Oct;77(19):10714-8. doi: 10.1128/jvi.77.19.10714-10718.2003.

DOI:10.1128/jvi.77.19.10714-10718.2003
PMID:12970460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC228484/
Abstract

The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-x(L) transcript versus the Bcl-x(S) transcript in Neuro-2A cells. Bcl-x(L) encodes an antiapoptotic protein, whereas Bcl-x(S) encodes a proapoptotic protein. Promoting the accumulation of Bcl-x(L) in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.

摘要

单纯疱疹病毒1型潜伏相关转录物（LAT）可抑制细胞凋亡。我们在此证明，LAT影响神经2A细胞中Bcl-x(L)转录本与Bcl-x(S)转录本的积累。Bcl-x(L)编码一种抗凋亡蛋白，而Bcl-x(S)编码一种促凋亡蛋白。促进神经元中Bcl-x(L)的积累可能会抑制细胞凋亡，从而增强潜伏-激活周期。