编码单纯疱疹病毒1型潜伏相关转录物的基因会影响编码凋亡调节蛋白的转录物（Bcl-x(L)和Bcl-x(S)）的积累。
The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins.
作者信息
Peng Weiping, Henderson Gail, Perng Guey-Chuen, Nesburn Anthony B, Wechsler Steven L, Jones Clinton
机构信息
Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska 68583-0905, USA.
出版信息
J Virol. 2003 Oct;77(19):10714-8. doi: 10.1128/jvi.77.19.10714-10718.2003.
Abstract
The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-x(L) transcript versus the Bcl-x(S) transcript in Neuro-2A cells. Bcl-x(L) encodes an antiapoptotic protein, whereas Bcl-x(S) encodes a proapoptotic protein. Promoting the accumulation of Bcl-x(L) in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.
摘要
单纯疱疹病毒1型潜伏相关转录物（LAT）可抑制细胞凋亡。我们在此证明，LAT影响神经2A细胞中Bcl-x(L)转录本与Bcl-x(S)转录本的积累。Bcl-x(L)编码一种抗凋亡蛋白，而Bcl-x(S)编码一种促凋亡蛋白。促进神经元中Bcl-x(L)的积累可能会抑制细胞凋亡，从而增强潜伏-激活周期。
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The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins.编码单纯疱疹病毒1型潜伏相关转录物的基因会影响编码凋亡调节蛋白的转录物（Bcl-x(L)和Bcl-x(S)）的积累。
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