检测对人疱疹病毒6型复制和潜伏可有可无的基因簇。
Detection of a gene cluster that is dispensable for human herpesvirus 6 replication and latency.
作者信息
Kondo Kazuhiro, Nozaki Hideo, Shimada Kazuya, Yamanishi Koichi
机构信息
Department of Microbiology, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan.
出版信息
J Virol. 2003 Oct;77(19):10719-24. doi: 10.1128/jvi.77.19.10719-10724.2003.
Abstract
The U3-U7 gene cluster of human herpesvirus 6 (HHV-6) was replaced with an enhanced green fluorescent protein-puromycin gene cassette containing the cytomegalovirus major immediate-early promoter. Neither viral replication in T cells nor latency and reactivation in macrophages was impaired. During HHV-6 latency, the cytomegalovirus promoter used the transcription start sites employed in cytomegalovirus latency.
摘要
人类疱疹病毒6型（HHV-6）的U3-U7基因簇被一个含有巨细胞病毒主要立即早期启动子的增强型绿色荧光蛋白-嘌呤霉素基因盒所取代。T细胞中的病毒复制以及巨噬细胞中的潜伏和再激活均未受损。在HHV-6潜伏期间，巨细胞病毒启动子使用了巨细胞病毒潜伏时所采用的转录起始位点。
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J Virol. 2003 Feb;77(3):2258-64. doi: 10.1128/jvi.77.3.2258-2264.2003.
2
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J Virol. 2003 Jan;77(1):631-41. doi: 10.1128/jvi.77.1.631-641.2003.
3
Characterisation of a human herpesvirus 6 variant A 'amplicon' and replication modulation by U94-Rep 'latency gene'.
J Virol Methods. 2002 Sep;105(2):331-41. doi: 10.1016/s0166-0934(02)00130-1.
4
Identification of human herpesvirus 6 latency-associated transcripts.人类疱疹病毒6型潜伏相关转录本的鉴定。
J Virol. 2002 Apr;76(8):4145-51. doi: 10.1128/jvi.76.8.4145-4151.2002.
5
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Clin Infect Dis. 2001 Sep 15;33(6):829-33. doi: 10.1086/322691. Epub 2001 Aug 10.
6
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