人类疱疹病毒-6 潜伏和端粒整合的分子生物学。
The molecular biology of human herpesvirus-6 latency and telomere integration.
机构信息
Department of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA.
出版信息
Microbes Infect. 2011 Aug;13(8-9):731-41. doi: 10.1016/j.micinf.2011.03.006. Epub 2011 Mar 31.
Abstract
The genomes of herpesviruses establish latency as a circular episome. However, Human herpesvirus-6 (HHV-6) has been shown to specifically integrate into the telomeres of chromosomes during latency and vertically transmit through the germ-line. This review will focus on the telomere integration of HHV-6, the potential viral and cellular genes that mediate integration, and the clinical impact on the host.
摘要
疱疹病毒的基因组以环状染色体外体的形式建立潜伏感染。然而，人类疱疹病毒 6（HHV-6）已被证明在潜伏感染期间特异性整合到染色体的端粒，并通过生殖细胞垂直传播。本文将重点讨论 HHV-6 的端粒整合、介导整合的潜在病毒和细胞基因，以及对宿主的临床影响。
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