Filipek B, Krupińska J, Zebala K, Szymańska I, Librowski T, Piekoszewski W
Department of Pharmacology, Medical Academy, Kraków, Poland.
Pol J Pharmacol Pharm. 1992 Sep-Oct;44(5):443-52.
The aim of this work was to determine the influence of ethanol on the antiarrhythmic activity of verapamil in the model of calcium arrhythmia in rats non-dependent and dependent on ethanol. The results of the experiment show that a combined, single administration of ethanol and verapamil attenuates in a statistically significant manner the antiarrhythmic effect of verapamil. Ethanol administered repeatedly together with verapamil does not diminish the antiarrhythmic activity of verapamil.
本研究的目的是确定乙醇对维拉帕米在非乙醇依赖和乙醇依赖大鼠钙心律失常模型中抗心律失常活性的影响。实验结果表明，乙醇和维拉帕米联合单次给药以统计学上显著的方式减弱了维拉帕米的抗心律失常作用。与维拉帕米反复联合给药的乙醇不会降低维拉帕米的抗心律失常活性。
