Filipek B, Krupińska J, Szymańska I, Zebala K, Librowski T, Piekoszewski W
Department of Pharmacodynamics, Medical Academy, Kraków, Poland.
Pol J Pharmacol Pharm. 1992 Sep-Oct;44(5):453-60.
The antiarrhythmic action of diltiazem in the model of barium arrhythmia was studied in rats non-dependent and dependent on ethanol. The results of our studies showed that single intragastric administration of ethanol jointly with diltiazem did not significantly attenuate the antiarrhythmic effect of diltiazem. Ethanol administered repeatedly and jointly with diltiazem influenced the antiarrhythmic action of diltiazem in different ways, depending on the used dose of diltiazem. After repeated joint administration of ethanol and diltiazem in a lower dose, attenuation of the antiarrhythmic effect of diltiazem was not observed. Repeated joint administration of ethanol and diltiazem in a higher dose attenuated the antiarrhythmic effect of diltiazem. Those experiments also showed that single administration of diltiazem did not significantly influence the ethanol level in the blood; however, when administered repeatedly, diltiazem reduced the concentration of ethanol in blood.
在非乙醇依赖和乙醇依赖大鼠中研究了地尔硫䓬在钡剂诱发心律失常模型中的抗心律失常作用。我们的研究结果表明，乙醇与地尔硫䓬联合单次灌胃给药不会显著减弱地尔硫䓬的抗心律失常作用。乙醇与地尔硫䓬重复联合给药对地尔硫䓬抗心律失常作用的影响因所用的地尔硫䓬剂量而异。乙醇与较低剂量地尔硫䓬重复联合给药后，未观察到地尔硫䓬抗心律失常作用减弱。乙醇与较高剂量地尔硫䓬重复联合给药减弱了地尔硫䓬的抗心律失常作用。这些实验还表明，单次给予地尔硫䓬对血液中的乙醇水平无显著影响；然而，重复给药时，地尔硫䓬降低了血液中乙醇的浓度。
