香豆素和色烯新氨基烷氧基衍生物的合成及中枢药理筛选
Synthesis and central pharmacological screening of new aminoalkoxy derivatives of coumarin and chromene.
作者信息
Suski S, Zawadowski T, Bogdal M, Przemyk B, Szafrański B
机构信息
Department of Chemistry, Medical Academy, Warszawa, Poland.
出版信息
Pol J Pharmacol Pharm. 1992 Sep-Oct;44(5):475-85.
PMID:1297112
Abstract
Several 8-(2- and 3-aminoalkoxy) derivatives of coumarin and 5-(2- and 3-aminoalkoxy) derivatives of chromene have been synthesized. The strongest, although short-time neurodepressive activity was exhibited by 8-[3-(4-phenyl-1-piperazinyl)propoxy]-7-methoxycoumarin hydrochloride 15.
摘要
已合成了几种香豆素的8 -（2 - 和3 - 氨基烷氧基）衍生物以及色烯的5 -（2 - 和3 - 氨基烷氧基）衍生物。8 - [3 -（4 - 苯基 - 1 - 哌嗪基）丙氧基] - 7 - 甲氧基香豆素盐酸盐15表现出最强的神经抑制活性，尽管其作用时间较短。
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