节律与锂的药理学

Rhythms and the pharmacology of lithium.

作者信息

Klemfuss H

机构信息

Department of Psychiatry, University of California, San Diego.

出版信息

Pharmacol Ther. 1992;56(1):53-78. doi: 10.1016/0163-7258(92)90037-z.

DOI:10.1016/0163-7258(92)90037-z

PMID:1297145

Abstract

Lithium is the treatment of choice for bipolar affective disorder (manic-depression) and is useful in other recurrent affective and nonaffective illnesses. This review discusses lithium's actions on period, phase, amplitude and coupling of biological rhythms that may relate to its therapeutic effectiveness. Alternatively, lithium might interact with environmental light to influence circadian rhythms by an action on the retina. The mechanisms responsible for lithium's chronopharmacological actions are not known, but cellular cations, phosphoinositide or adenylate cyclase second messenger systems, hormones and neurotransmitters may all be involved.

摘要

锂是治疗双相情感障碍（躁郁症）的首选药物，对其他复发性情感性和非情感性疾病也有效。本综述讨论了锂对生物节律的周期、相位、振幅和耦合的作用，这些作用可能与其治疗效果相关。另外，锂可能通过作用于视网膜与环境光相互作用，从而影响昼夜节律。锂的时辰药理学作用机制尚不清楚，但细胞阳离子、磷酸肌醇或腺苷酸环化酶第二信使系统、激素和神经递质可能都参与其中。