洪水后儿童急性不明原因发热的病因

The etiology of acute pyrexia of unknown origin in children after a flood.

作者信息

Pradutkanchana Jintana, Pradutkanchana Sukone, Kemapanmanus Marisa, Wuthipum Nathakul, Silpapojakul Kamkarn

机构信息

Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 2003 Mar;34(1):175-8.

PMID:12971532

Abstract

Acute pyrexia of unknown origin (PUO) is a major public health problem in Thailand. We studied the etiology of 180 cases of acute PUO in children after a sudden severe flood in Hat Yai city in 2000. Dengue infection and leptospirosis accounted for more than half of the total cases. Dengue hemorrhagic fever was the most common (29.4%) followed by leptospirosis (27.2%) and scrub typhus infection (1.1%). Five serovars of leptospires were involved in this study. Leptospira interrogans bataviae was the most common (86.5%). Acute serum antibody testing could detect only 52.8% and 40.8% of dengue and leptospirosis cases, respectively. This study showed both should be included in the presumptive diagnosis of acute PUO in patients after flooding.

摘要

急性不明原因发热（PUO）是泰国的一个主要公共卫生问题。我们研究了2000年合艾市突发严重洪水后180例儿童急性PUO的病因。登革热感染和钩端螺旋体病占总病例的一半以上。登革出血热最为常见（29.4%），其次是钩端螺旋体病（27.2%）和恙虫病感染（1.1%）。本研究涉及5种钩端螺旋体血清型。爪哇群问号钩端螺旋体最为常见（86.5%）。急性血清抗体检测分别仅能检测出52.8%的登革热病例和40.8%的钩端螺旋体病病例。这项研究表明，在洪水过后的患者急性PUO的推定诊断中，两者都应被纳入考虑。