Heisey G B, Nimmanitya S, Karnchanachetanee C, Tingpalapong M, Samransamruajkit S, Hansukjariya P, Elwell M R, Ward G S
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1988 Jun;19(2):317-22.
Patients with FUOs at the Children's Hospital in Bangkok and the Chao Phya Abhai Bhu Bejhr Hospital in Prachinburi were screened for leptospirosis by blood and urine culture in addition to microagglutination testing of their serum. Animal populations in urban and periurban areas of Bangkok were surveyed for evidence of leptospira infection. Three rural sites near the Prachinburi Provincial Hospital were also surveyed. The rodents' and domestic animals' blood, urine, and/or kidney cell samples were cultured for leptospira. Sera from these animals were also tested for leptospira antibody. The bataviae serovar was the most commonly detected leptospiral agent in both man and animals. Presenting symptoms varied with age with children showing primarily fever, vomiting, headache, abdominal and generalized muscle pain and diarrhea whereas adults had fever, headache, anorexia, muscle pain and constipation. Blood samples from patients suspected of having leptospirosis were tested for antibody by the MAT and cultured in EMJH media. The following serogroups were identified: bataviae, autumanalis, javanica, hebdomadis, and pyrogens. Leptospirosis incidence in humans was much higher in the rainy/flooding year of 1983 compared to the relatively dry year of 1984. Results of our animal surveillance studies indicate that in addition to rats, which have previously been mentioned, dogs, bandicoots, cattle and pigs could be the source of human leptospirosis infection in both urban and provincial locations in Thailand.
曼谷儿童医院和北柳府的差夫雅阿派·布贝吉尔医院收治的不明原因发热（FUO）患者，除了对其血清进行显微凝集试验外，还通过血液和尿液培养来筛查钩端螺旋体病。对曼谷市区和郊区的动物群体进行了调查，以寻找钩端螺旋体感染的证据。还对北柳府省医院附近的三个农村地点进行了调查。对啮齿动物和家畜的血液、尿液和/或肾细胞样本进行钩端螺旋体培养。还对这些动物的血清进行钩端螺旋体抗体检测。在人和动物中，最常检测到的钩端螺旋体病原体是巴达维亚血清型。出现的症状因年龄而异，儿童主要表现为发热、呕吐、头痛、腹部和全身肌肉疼痛以及腹泻，而成人则有发热、头痛、厌食、肌肉疼痛和便秘。对疑似患有钩端螺旋体病患者的血样进行显微凝集试验抗体检测，并在EMJH培养基中培养。鉴定出以下血清群：巴达维亚、秋季、爪哇、七日热和致热。与相对干燥的1984年相比，1983年雨季/洪水年人类钩端螺旋体病发病率要高得多。我们动物监测研究的结果表明，除了之前提到的大鼠外，狗、袋狸、牛和猪可能是泰国城市和乡村地区人类钩端螺旋体病感染的来源。
