Gojo Satoshi, Umezawa Akihiro
Department of Cardiovascular Surgery, Saitama Medical Center, Kawagoe, Japan.
Hum Cell. 2003 Mar;16(1):23-30. doi: 10.1111/j.1749-0774.2003.tb00125.x.
The phenomenon of regeneration is of growing interest to medical researchers. Until recently this was an area in which research in flatworms and newts predominated, but there is now a proliferation of research concerning regeneration in virtually all of the organs, not only the heart. One of the object is restoration of function to a failing heart through cell transplantation, and there have been many reports seeking donor sources of somatic stem cells, i.e.: stem cells in marrow or skeletal muscle and ES cells, beginning with those in embryonic myocardial cell transplant experiments. In particular, reports of mesenchymal stem cell differentiation into nerve cell, myocardial cell, skeletal muscle cell, and vascular endothelial cell series have drawn attention to cell plasticity, and clinical applications are awaited.
再生现象越来越受到医学研究人员的关注。直到最近，这还是一个以涡虫和蝾螈研究为主导的领域，但现在几乎所有器官的再生研究都在激增，不仅仅是心脏。其中一个目标是通过细胞移植恢复衰竭心脏的功能，并且有许多报告在寻找体干细胞的供体来源，即：骨髓或骨骼肌中的干细胞以及胚胎干细胞，从胚胎心肌细胞移植实验开始。特别是，关于间充质干细胞分化为神经细胞、心肌细胞、骨骼肌细胞和血管内皮细胞系的报告引起了对细胞可塑性的关注，人们期待着其临床应用。
