Yazawa Takashi, Imamichi Yoshitaka, Miyamoto Kaoru, Umezawa Akihiro, Taniguchi Takanobu
Takashi Yazawa, Takanobu Taniguchi, Department of Biochemistry, Asahikawa Medical University, Hokkaido 078-8510, Japan.
World J Stem Cells. 2014 Apr 26;6(2):203-12. doi: 10.4252/wjsc.v6.i2.203.
Hormone replacement therapy is necessary for patients with adrenal and gonadal failure. Steroid hormone treatment is also employed in aging people for sex hormone deficiency. These patients undergo such therapies, which have associated risks, for their entire life. Stem cells represent an innovative tool for tissue regeneration and the possibility of solving these problems. Among various stem cell types, mesenchymal stem cells have the potential to differentiate into steroidogenic cells both in vivo and in vitro. In particular, they can effectively be differentiated into steroidogenic cells by expressing nuclear receptor 5A subfamily proteins (steroidogenic factor-1 and liver receptor homolog-1) with the aid of cAMP. This approach will provide a source of cells for future regenerative medicine for the treatment of diseases caused by steroidogenesis deficiencies. It can also represent a useful tool for studying the molecular mechanisms of steroidogenesis and its related diseases.
激素替代疗法对于肾上腺和性腺功能衰竭患者是必要的。类固醇激素治疗也用于老年人的性激素缺乏症。这些患者一生都要接受此类有相关风险的治疗。干细胞是组织再生的创新工具，也是解决这些问题的可能途径。在各种干细胞类型中，间充质干细胞在体内和体外都有分化为类固醇生成细胞的潜力。特别是，它们可以借助环磷酸腺苷（cAMP）表达核受体5A亚家族蛋白（类固醇生成因子-1和肝脏受体同源物-1），从而有效地分化为类固醇生成细胞。这种方法将为未来再生医学提供细胞来源，用于治疗由类固醇生成缺陷引起的疾病。它还可以成为研究类固醇生成及其相关疾病分子机制的有用工具。
