Nogueira R M, Miagostovich M P, Cavalcanti S M, Marzochi K B, Schatzmayr H G
Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro.
Res Virol. 1992 Nov-Dec;143(6):423-7. doi: 10.1016/s0923-2516(06)80136-6.
The appearance and persistence of IgM antibodies were studied by MAC-ELISA in 926 confirmed cases of dengue virus type 1 infection. Assays performed on acute and convalescent patient sera revealed that IgM antibodies appeared during the early phase of disease (day 2) and persisted for three months after onset. MAC-ELISA proved to be a valuable early diagnosis test when compared with haemagglutination inhibition.
采用MAC - ELISA法对926例确诊的1型登革病毒感染病例的IgM抗体出现情况及持续时间进行了研究。对急性期和恢复期患者血清进行检测发现，IgM抗体在疾病早期（第2天）出现，并在发病后持续三个月。与血凝抑制试验相比，MAC - ELISA被证明是一种有价值的早期诊断检测方法。
