Nogueira R M, Miagostovich M P, Lampe E, Souza R W, Zagne S M, Schatzmayr H G
Departamento de Virologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Epidemiol Infect. 1993 Aug;111(1):163-70. doi: 10.1017/s0950268800056788.
During 1990 and 1991, dengue fever was detected in the State of Rio de Janeiro, Brazil. It occurred in two epidemic waves; one, from January to August 1990, caused predominantly by dengue virus type 1 (DEN-1) the other from October 1990 to May 1991 caused by type 2 virus (DEN-2). Dengue was confirmed by virus isolation and/or IgM capture enzyme-linked immunosorbent assay (MAC-ELISA) in 2109/5964 (35.4%) of the cases. DEN-2 virus was isolated from 180 patients. HAI tests indicated that of these previous infection with DEN-1 had occurred in 130 (72%). The epidemic was classified as dengue fever, but severe and even fatal cases occurred in association with secondary infection.
1990年至1991年期间，巴西里约热内卢州发现了登革热。它以两次疫情的形式出现；一次是1990年1月至8月，主要由1型登革热病毒（DEN-1）引起，另一次是1990年10月至1991年5月，由2型病毒（DEN-2）引起。通过病毒分离和/或IgM捕获酶联免疫吸附测定（MAC-ELISA）在2109/5964（35.4%）病例中确诊为登革热。从180名患者中分离出了DEN-2病毒。血凝抑制试验表明，在这些患者中，130人（72%）曾感染过DEN-1。此次疫情被归类为登革热，但严重甚至致命的病例与继发感染有关。
