Bandaletova T Y
International Agency for Research on Cancer, Lyon, France.
Tumori. 1992 Dec 31;78(6):366-9. doi: 10.1177/030089169207800603.
Alterations of intestinal lymphoid patches induced by cyclosporine A (CS-A) were studied in male Fischer 344 rats. Continuous treatment with CS-A (10 mg/kg b.w. by gavage daily) resulted in lymphocyte deficiency of the intestinal lymphoid patches followed by progressive replacement of the lymphoid tissue by cystic and glandular epithelial structures and single cells positive for epithelium-associated immunohistochemical markers. Cessation of CS-A administration led to regression of the alterations and a moderate recovery of the lymphoid patches. Morphologic changes induced at the epithelial-lymphoid border may be a useful parameter to estimate immunotoxicity.
在雄性Fischer 344大鼠中研究了环孢素A（CS-A）诱导的肠道淋巴滤泡改变。连续给予CS-A（每天经口灌胃10 mg/kg体重）导致肠道淋巴滤泡淋巴细胞缺乏，随后淋巴组织逐渐被囊性和腺性上皮结构以及上皮相关免疫组化标记阳性的单个细胞取代。停止给予CS-A导致这些改变消退，淋巴滤泡有一定程度的恢复。上皮-淋巴边界处诱导的形态学变化可能是评估免疫毒性的一个有用参数。
