Finke Daniela
Department of Biomedicine, Developmental Immunology, University of Basel, Basel, Switzerland.
Semin Immunopathol. 2009 Jul;31(2):151-69. doi: 10.1007/s00281-009-0163-6. Epub 2009 Jun 9.
Since the discovery of inducer cells as a separate lineage for organogenesis of Peyer's patches in the small intestine of fetal mice, a lot of progress has been made in understanding the molecular pathways involved in the generation of lymphoid tissue and the maintenance of the lymphoid architecture. The findings that inducer cells also exist in adult mice and in humans, have a lineage relationship to natural killer cells, and can be stimulated during infections highlight their possible role in establishing innate and adaptive immune responses. Novel concepts in the development of intestinal lymphoid tissues have been made in the past few years suggesting that lymphoid organs are more plastic as previously thought and depend on antigenic stimulation. In addition, the generation of novel lymphoid organs in the gut under inflammatory conditions indicates a function in chronic diseases. The present review summarizes current knowledge on the basic framework of signals required for developing lymphoid tissue under normal and inflammatory conditions.
自从发现诱导细胞是胎鼠小肠派尔集合淋巴结器官发生的一个独立谱系以来，在理解参与淋巴组织生成和维持淋巴结构的分子途径方面已经取得了很大进展。诱导细胞也存在于成年小鼠和人类中，与自然杀伤细胞有谱系关系，并且在感染期间可被刺激，这些发现突出了它们在建立先天性和适应性免疫反应中的可能作用。在过去几年中，肠道淋巴组织发育方面出现了新的概念，表明淋巴器官比以前认为的更具可塑性，并且依赖于抗原刺激。此外，炎症条件下肠道中新型淋巴器官的生成表明其在慢性疾病中的作用。本综述总结了目前关于正常和炎症条件下淋巴组织发育所需信号基本框架的知识。
