Bruschi M L, Cardoso M L C, Lucchesi M B, Gremião M P D
Departamento de Farmácia e Farmacologia, Universidade Estadual de Maringá, Av. Colombo 5790, CEP 87020-900, Maringá, PR, Brazil.
Int J Pharm. 2003 Oct 2;264(1-2):45-55. doi: 10.1016/s0378-5173(03)00386-7.
Gelatin microparticles containing propolis extractive solution (PES) were prepared by spray-drying technique. The optimization of the spray-drying operating conditions and the proportions of gelatin and mannitol were investigated. Regular particle morphology was obtained when mannitol was used, whereas mannitol absence produced a substantial number of coalesced and agglomerated microparticles. Microparticles had a mean diameter of 2.70 microm without mannitol and 2.50 microm with mannitol. The entrapment efficiency for propolis of the microparticles was upto 41% without mannitol and 39% with mannitol. The microencapsulation by spray-drying technique maintained the activity of propolis against Staphylococcus aureus. These gelatin microparticles containing propolis would be useful for developing intermediary or eventual propolis dosage form without the PES' strong and unpleasant taste, aromatic odour, and presence of ethanol.
采用喷雾干燥技术制备了含蜂胶提取液（PES）的明胶微粒。研究了喷雾干燥操作条件以及明胶和甘露醇比例的优化。使用甘露醇时可获得规则的颗粒形态，而不使用甘露醇则会产生大量聚结和团聚的微粒。不使用甘露醇时微粒的平均直径为2.70微米，使用甘露醇时为2.50微米。微粒对蜂胶的包封率在不使用甘露醇时高达41%，使用甘露醇时为39%。通过喷雾干燥技术进行微囊化可保持蜂胶对金黄色葡萄球菌的活性。这些含蜂胶的明胶微粒将有助于开发中间或最终的蜂胶剂型，避免PES强烈且难闻的味道、芳香气味以及乙醇的存在。
