Miladi K, Ibraheem D, Iqbal M, Sfar S, Fessi H, Elaissari A
University of Lyon, France; Lyon 1 University, Villeurbanne, CNRS, UMR 5007, Laboratoire d'Automatique et de Génie des Procédés, LAGEP-CPE-308G, Villeurbanne, France ; University of Monastir, Laboratoire de pharmacie galénique, Rue Avicenne, 5000 Monastir, Tunisia.
University of Lyon, France; Lyon 1 University, Villeurbanne, CNRS, UMR 5007, Laboratoire d'Automatique et de Génie des Procédés, LAGEP-CPE-308G, Villeurbanne, France.
EXCLI J. 2014 Feb 3;13:28-57. eCollection 2014.
Biodegradable and biocompatible polymers are widely used for the encapsulation of drug molecules. Various particulate carriers with different sizes and characteristics have been prepared by miscellaneous techniques. In this review, we reported the commonly used preformed polymer based techniques for the preparation of micro and nano-structured materials intended for drug encapsulation. A description of polymer-solvent interaction was provided. The most widely used polymers were reported and described and their related research studies were mentioned. Moreover, principles of each technique and its crucial operating conditions were described and discussed. Recent applications of all the reported techniques in drug delivery were also reviewed.
可生物降解且生物相容的聚合物被广泛用于药物分子的包封。通过各种技术制备了具有不同尺寸和特性的各种颗粒载体。在本综述中，我们报道了用于制备用于药物包封的微米和纳米结构材料的常用预制聚合物基技术。提供了聚合物 - 溶剂相互作用的描述。报道并描述了最广泛使用的聚合物，并提及了它们的相关研究。此外，描述并讨论了每种技术的原理及其关键操作条件。还综述了所有报道技术在药物递送中的最新应用。
