Ekin Suat, Mert Nihat, Gunduz Handan, Meral Ismail
Department of Biochemistry, Yuzuncu Yil University, 65080 Van, Turkey.
Biol Trace Elem Res. 2003 Sep;94(3):193-201. doi: 10.1385/BTER:94:3:193.
The aim of the present study was to investigate whether altered serum total sialic acid (TSA), lipid-associated sialic acid (LSA), copper (Cu), manganese (Mn), zinc (Zn), chromium (Cr), iron (Fe), and magnesium (Mg) levels had an interactive connection with diabetes and also whether they were correlated with each other in diabetic patients. Two study groups (control and type 2 diabetic subjects) were included. Two hundred patients (108 female and 92 male), diagnosed and treated for type 2 diabetes in the Yuzuncu Yil University Hospital (Van, Turkey), were selected consecutively to represent type 2 diabetic patients. Fifty healthy individuals (29 female and 21 male) served as the control group matched for age, sex, body mass index, and smoking status were selected from hospital staff and other outpatient clinics. All participants had not taken vitamin or mineral supplements for at least 2 wk before sampling. Blood samples were drawn after an overnight fasting in both groups for the determination of serum glucose, TSA, LSA, Cu, Zn, Mn, Cr, Fe, and Mg. It was found that diabetics had higher TSA, LSA, Fe, Mn, Fe/Zn, and Cu/Zn levels, and lower Zn and Mg levels than those of controls. Although, Cu levels were higher, and Cr levels were lower in total and male diabetic patients, they were not different in female diabetic patients than in controls. The Cu/Fe ratio was lower in total and female diabetic patients, but not different in male diabetic patients than controls. The Zn/Cr ratio, on the other hand, was not different in diabetics than in controls. There was only a positive correlation between Fe-Mn levels in male diabetic patients. There was a negative correlation in LSA-Mn, Fe-Cu, Cu-Fe/Zn, and Mn-Cu/Zn levels in total diabetic patients. There was a positive correlation in TSA-Cr, TSA-Mg, LSA-Cu/Fe, LSA-Zn/Cr levels, and a negative correlation in TSA-Cu/Zn, LSA-Mn, Fe-Cu, Mn-Cu, Cu-Fe/Zn, Fe-cholesterol, and Cr-cholesterol in female diabetic patients. Our results showed that TSA, LSA, and selected minerals have interactive connections with diabetes mellitus (DM). There are also many sex-related positive or negative correlations between the altered parameters in diabetic patients. These parameters might be used as diagnostic index in patients with DM.
本研究的目的是调查血清总唾液酸（TSA）、脂质相关唾液酸（LSA）、铜（Cu）、锰（Mn）、锌（Zn）、铬（Cr）、铁（Fe）和镁（Mg）水平的改变是否与糖尿病存在交互联系，以及它们在糖尿病患者中是否相互关联。研究纳入了两个组（对照组和2型糖尿病患者组）。从土耳其凡城的于祖尔祖尔大学医院连续选取了200例已确诊并接受治疗的2型糖尿病患者（108例女性和92例男性）以代表2型糖尿病患者。从医院工作人员和其他门诊中选取了50名健康个体（29例女性和21例男性）作为对照组，对照组在年龄、性别、体重指数和吸烟状况方面进行了匹配。所有参与者在采样前至少2周未服用维生素或矿物质补充剂。两组均在空腹过夜后采集血样，以测定血清葡萄糖、TSA、LSA、Cu、Zn、Mn、Cr、Fe和Mg。结果发现，糖尿病患者的TSA、LSA、Fe、Mn、Fe/Zn和Cu/Zn水平高于对照组，而Zn和Mg水平低于对照组。虽然总体糖尿病患者和男性糖尿病患者的Cu水平较高，Cr水平较低，但女性糖尿病患者与对照组相比无差异。总体糖尿病患者和女性糖尿病患者的Cu/Fe比值较低，但男性糖尿病患者与对照组相比无差异。另一方面，糖尿病患者的Zn/Cr比值与对照组无差异。仅男性糖尿病患者的Fe-Mn水平之间存在正相关。总体糖尿病患者的LSA-Mn、Fe-Cu、Cu-Fe/Zn和Mn-Cu/Zn水平存在负相关。女性糖尿病患者的TSA-Cr、TSA-Mg、LSA-Cu/Fe、LSA-Zn/Cr水平存在正相关，而TSA-Cu/Zn、LSA-Mn、Fe-Cu、Mn-Cu、Cu-Fe/Zn、Fe-胆固醇和Cr-胆固醇水平存在负相关。我们的结果表明，TSA、LSA和选定的矿物质与糖尿病（DM）存在交互联系。糖尿病患者中改变的参数之间也存在许多与性别相关的正相关或负相关。这些参数可作为糖尿病患者的诊断指标。
