Gusmão Fábio A F, Tavares Eraldo J M, Moreira Lília Maria de Azevedo
Instituto de Biologia, Universidade Federal da Bahia, Salvador, BA, 40170-290, Brasil.
Cad Saude Publica. 2003 Jul-Aug;19(4):973-8. doi: 10.1590/s0102-311x2003000400020. Epub 2003 Sep 8.
This study analyzes the association between advanced maternal age and increased incidence of Down syndrome in neonates, based on a population sample from the State of Bahia in Northeast Brazil. Age of the mothers of 220 Down syndrome subjects was investigated, and age distribution was compared to that of the population control group, 220 mothers of subjects without Down syndrome. The proportion of Down syndrome infants dependent on advanced maternal age was estimated at 43.6%, thus showing a high correlation (r = 0.95) between advanced maternal age and Down syndrome incidence. However, this component was significantly lower than the 75% reported in the literature. The component independent of maternal age was estimated at 56.4%, indicating the action of other factors on meiotic non-disjunction associated with 21 trisomy. The results also indicate that despite the regional characteristics of Northeast Brazil, factors both dependent and independent of maternal age show the same distribution observed in Southeast Brazil, where extensive studies have been performed.
本研究基于巴西东北部巴伊亚州的人口样本，分析了高龄产妇与新生儿唐氏综合征发病率增加之间的关联。调查了220名唐氏综合征患儿母亲的年龄，并将年龄分布与人口对照组（220名非唐氏综合征患儿母亲）进行了比较。估计依赖高龄产妇的唐氏综合征婴儿比例为43.6%，因此显示高龄产妇与唐氏综合征发病率之间存在高度相关性（r = 0.95）。然而，这一比例显著低于文献报道的75%。与产妇年龄无关的比例估计为56.4%，表明其他因素对与21三体相关的减数分裂不分离有影响。结果还表明，尽管巴西东北部具有区域特征，但与产妇年龄相关和无关的因素显示出与巴西东南部相同的分布，巴西东南部已进行了广泛研究。
