Ljubicić Neven, Supanc Vladimir, Roić Goran, Sharma Mirella
Division of Gastroenterology, Department of Internal Medicine, University Hospital Sestre Milosrdnice, Zagreb, Croatia.
Coll Antropol. 2003 Jun;27(1):189-95.
The aim of this study was to investigate both the efficacy and safety of sedation with propofol during urgent therapeutic gastroscopy in patients with upper gastrointestinal bleeding. This prospective study included a total of 110 patients. Propofol was administered intravenously at the starting dose of 1 mg/kg body weight and was followed by repeated doses. Oxygen saturation and heart rate were monitored by pulse oxymetry. The mean dose of propofol administered was 161 +/- 49 mg. Urgent upper GI endoscopy under propofol sedation was successful in 98% of cases. Endoscopists rated the sedation as good in 83.6%, satisfactory in 14.5%, and poor in 1.8% of patients. Potentially harmful drop in oxygen saturation below 85% was observed in 5.5% of patients, whereas a temporary drop in heart rate below 50 beats/min was observed in 11.8%, not requiring any intervention. Almost 93% of patients could not remember the beginning or the end of the intervention. This data demonstrates that sedation with propofol is suitable for use in patients with upper gastrointestinal bleeding undergoing urgent endoscopy.
本研究旨在探讨丙泊酚镇静在急性上消化道出血患者急诊治疗性胃镜检查中的有效性和安全性。这项前瞻性研究共纳入了110例患者。丙泊酚以1mg/kg体重的起始剂量静脉给药，随后重复给药。通过脉搏血氧饱和度仪监测血氧饱和度和心率。丙泊酚的平均给药剂量为161±49mg。98%的病例在丙泊酚镇静下成功完成急诊上消化道内镜检查。内镜医师将83.6%的患者镇静效果评为良好，14.5%评为满意，1.8%评为差。5.5%的患者观察到血氧饱和度潜在有害性下降至85%以下，而11.8%的患者观察到心率暂时下降至50次/分钟以下，无需任何干预。近93%的患者记不起干预的开始或结束。这些数据表明，丙泊酚镇静适用于急性上消化道出血患者的急诊内镜检查。
