Xiao Dinghua, Wang Fen, Wang Xiaoyan, Tang Wuliang, Yang Hui, Shen Shourong
Department of Gastroenterology, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Nov;35(11):1174-7. doi: 10.3969/j.issn.1672-7347.2010.11.010.
To investigate the efficacy and security of different administrations of propofol on the sedation in upper gastrointestinal endoscopic procedures in snoring patients.
A total of 1,117 patients with snoring in ASA I-II level, who underwent gastroscopy and received propofol as sedation, were assigned to Group A, Group B, and Group C.These groups had different administration methods of propofol. The dose of propofol, response to endoscopic procedures, changes of oxygen saturation of arterial blood (SPO₂), incidence of severe respiratory depression and sedation quality assessed by operators were observed.
The incidence of transient decline in SPO₂ in Group A, B, and C were 50.4%, 3.1%, and 18.5%, respectively. The doses of propofol of Group A, B, and C were (108.50±18.02) mg, (57.50±7.50) mg, and (79.80±10.02) mg, respectively, with significant difference (P<0.05). The incidence of severe respiratory depression in Group A was 1.2%, but Group B and C were 0%. Compared with Group A(100%) and C(100%), the satisfaction rate of sedation quality in Group B was 74%, with significant difference (P<0.05).
During the upper gastrointestinal endoscopic procedures, snoring patients are premedicated with propofol in various uses by steps or one slow administration. Both methods are safe and effective to reduce the incidence of severe respiratory depression, and patients have no memory of the procedure.
探讨丙泊酚不同给药方式用于鼾症患者上消化道内镜检查镇静的有效性及安全性。
选取1117例ASA I-II级鼾症患者，行胃镜检查并以丙泊酚进行镇静，分为A组、B组和C组，丙泊酚给药方式不同。观察丙泊酚用量、内镜操作反应、动脉血氧饱和度（SPO₂）变化、严重呼吸抑制发生率及操作者评估的镇静质量。
A组、B组和C组SPO₂短暂下降发生率分别为50.4%、3.1%和18.5%。A组、B组和C组丙泊酚用量分别为（108.50±18.02）mg、（57.50±7.50）mg和（79.80±10.02）mg，差异有统计学意义（P<0.05）。A组严重呼吸抑制发生率为1.2%，B组和C组为0%。B组镇静质量满意率为74%，与A组（100%）和C组（100%）比较，差异有统计学意义（P<0.05）。
上消化道内镜检查时，鼾症患者采用丙泊酚分次预注或一次缓慢推注等不同方式给药，两种方法均安全有效，可降低严重呼吸抑制发生率，患者对检查过程无记忆。
