Konopke R, Kersting S, Ockert D, Gastmeier J, Saeger H D
Klinik und Poliklinik für Viszeral-, Thorax- und Gefässchirurgie Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden.
Swiss Surg. 2003;9(4):173-80. doi: 10.1024/1023-9332.9.4.173.
The aim of this study was the evaluation of early results of esophageal resection for cancer including the assessment of pre-operative risk factors and post-operative mortality (risk score developed by Barthels et al. 1998).
One hundred and eighty one patients with esophageal cancer were operated with curative intention between October 1993 and December 2002. In a prospective analysis were reviewed: patient characteristics, characteristics of the esophageal cancer, part and type of esophageal resection, radicality, complications and mortality.
In total, a resection of the tumor could be achieved in 143 cases (79.0%). The overall complication rate was 52.5%, mainly cardio-pulmonary complications (25.9%) were seen. The surgical complications were determined by anastomotic leak (12.6%) and recurrent nerve injury (9.1%). Both types of complications were observed significantly more often after esophageal resection with a cervical anastomosis (p = 0.03 and p < 0.01). The hospital mortality was 8.4%. The 30 days mortality was 4.9%. Using a preoperative risk score retro- and prospectively, our data showed a lower mortality in patients with a low risk profile (2.4% and 2.3%) compared to those with a medium risk profile (7.4% and 6.4%). The only patient with a high risk profile died after resection.
The results of this analysis show that resection of esophageal cancer can be accomplished with acceptable morbidity and mortality. However, it has to be taken into account that the increase of pre-operative factors leads to an increase in post-operative mortality.
本研究旨在评估食管癌切除的早期结果,包括术前风险因素评估及术后死亡率(Barthels等人于1998年制定的风险评分)。
1993年10月至2002年12月期间,181例食管癌患者接受了根治性手术。对患者特征、食管癌特征、食管切除部位及类型、根治性、并发症及死亡率进行了前瞻性分析。
总共143例(79.0%)实现了肿瘤切除。总体并发症发生率为52.5%,主要为心肺并发症(25.9%)。手术并发症由吻合口漏(12.6%)和喉返神经损伤(9.1%)决定。食管切除术后行颈部吻合时,这两种并发症的发生率均显著更高(p = 0.03和p < 0.01)。医院死亡率为8.4%。30天死亡率为4.9%。前瞻性和回顾性地使用术前风险评分,我们的数据显示,与中度风险患者(7.4%和6.4%)相比,低风险患者的死亡率较低(2.4%和2.3%)。唯一的高风险患者术后死亡。
该分析结果表明,食管癌切除可在可接受的发病率和死亡率下完成。然而,必须考虑到术前因素的增加会导致术后死亡率上升。