Nafstad Per, Samuelsen Sven O, Irgens Lorentz M, Bjerkedal Tor
Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Eur J Epidemiol. 2003;18(8):755-61. doi: 10.1023/a:1025395405101.
Fetal life events may affect the development of the immune and/or respiratory system and increase the risk of asthma and allergic diseases. The objective of this study was to test the hypothesis that pregnancy complications are associated with the risk of developing asthma in the off-spring.
The study population comprised Norwegian live births 1967-1993 (n = 1,548,429) linking the Medical Birth Registry of Norway (MBRN) (exposure variables) and the National Insurance Administration Register (NIAR) (outcome variables), which covers all Norwegians. The MBRN variables included pregnancy complications, pregnancy outcomes and diseases of the mother. The NIAR provided data on all Norwegians who had received cash benefit for treatment of asthma from 1967 to 1996 (n = 5938, 3.9/1000 persons).
In multiple logistic regression analysis, pregnancy complications (International Classification of Diseases (ICD)-8-codes: 630-634) were associated with the risk of asthma (odds ratio 1.82, 95% confidence interval: 1.67-1.98). This was also the case if analyses were performed in different strata according to year of birth, plurality, maternal atopy, geographical district of birth, and maternal education.
Pregnancy complications may represent risk factors for the development of asthma in the offspring or express early signs of increased risk for developing the disease.
胎儿期生活事件可能会影响免疫和/或呼吸系统的发育，并增加患哮喘和过敏性疾病的风险。本研究的目的是检验以下假设：妊娠并发症与后代患哮喘的风险相关。
研究人群包括1967 - 1993年挪威的活产儿（n = 1,548,429），将挪威医疗出生登记处（MBRN）（暴露变量）和国家保险管理登记处（NIAR）（结局变量）相联系，后者涵盖所有挪威人。MBRN变量包括妊娠并发症、妊娠结局和母亲疾病。NIAR提供了1967年至1996年期间所有因哮喘治疗而领取现金补助的挪威人的数据（n = 5938，每1000人中有3.9人）。
在多因素逻辑回归分析中，妊娠并发症（国际疾病分类（ICD）-8编码：630 - 634）与哮喘风险相关（比值比1.82，95%置信区间：1.67 - 1.98）。根据出生年份、胎次、母亲特应性、出生地理区域和母亲教育程度在不同分层中进行分析时，情况也是如此。
妊娠并发症可能是后代患哮喘的危险因素，或者表明患该疾病风险增加的早期迹象。
