Reichman Nancy E, Nepomnyaschy Lenna
Department of Pediatrics, Robert Wood Johnson Medical School, 97 Paterson St., Room 435, New Brunswick, NJ 08903, USA.
Matern Child Health J. 2008 Nov;12(6):725-33. doi: 10.1007/s10995-007-0292-2. Epub 2007 Nov 7.
The objective of this study was to examine the relationship between maternal pre-pregnancy obesity and a diagnosis of asthma in offspring at age 3 years.
A population-based sample of children born in large U.S. cities in 1998-2000 was followed since birth (N=1971). The main outcome measure was whether the mother reported at 3 years that the child had ever been diagnosed with asthma. Multilevel logistic regression models were used to estimate the association between maternal pre-pregnancy obesity and child asthma diagnosis, as well as the extent to which the association can be explained by sociodemographic, medical, obstetric, and behavioral factors associated with both conditions.
Children with obese mothers had 52% higher odds of having an asthma diagnosis by age 3 (OR=1.52; 95% CI: 1.18-1.93). Sociodemographic, medical, obstetric, and behavioral factors explained some, but not all, of the association.
Maternal pre-pregnancy obesity is associated with diagnosis of asthma in offspring at age 3 years. The results from this study are preliminary and need to be replicated and further explored, but are suggestive of a complex intergenerational linkage between obesity and asthma.
本研究的目的是探讨孕前肥胖的母亲与3岁后代哮喘诊断之间的关系。
对1998 - 2000年在美国大城市出生的儿童进行基于人群的抽样研究，自出生起进行随访（N = 1971）。主要结局指标是母亲在孩子3岁时报告孩子是否曾被诊断为哮喘。采用多水平逻辑回归模型来估计孕前肥胖的母亲与儿童哮喘诊断之间的关联，以及该关联可由与这两种情况相关的社会人口统计学、医学、产科和行为因素解释的程度。
母亲肥胖的儿童在3岁时被诊断为哮喘的几率高52%（OR = 1.52；95% CI：1.18 - 1.93）。社会人口统计学、医学、产科和行为因素解释了部分而非全部关联。
孕前肥胖的母亲与3岁后代哮喘诊断有关。本研究结果是初步的，需要重复和进一步探索，但提示肥胖与哮喘之间存在复杂的代际联系。
