Young Alix, Jonski Grazyna, Rölla Gunnar
Department of Cariology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Eur J Oral Sci. 2003 Oct;111(5):400-4. doi: 10.1034/j.1600-0722.2003.00063.x.
Zinc ions, chlorhexidine (CHX) and cetylpyridinium chloride (CPC) are all known to inhibit production of volatile sulfur compounds (VSCs). The objective was to examine the anti-VSC dose-response effects of each of the above agents. Oral malodor was induced in 13 test subjects using the cysteine challenge method. The oral VSC response to rinses with 6 mm l-cysteine (pH 7.2) before and 1, 2 and 3 h after rinsing with zinc ions (Zn2+: 0.1, 0.3 and 1.0%), CHX and CPC (0.025 and 0.2%) was measured. Mouth air was analysed for VSC by gas chromatography (GC) according to current methodology. Zinc had a marked dose- and time-dependent anti-VSC effect. Zinc at 1% concentration had a somewhat unpleasant taste, whereas the lowest concentration was found acceptable. Chlorhexidine maintained a moderate anti-VSC effect over time. At 3 h, 0.2% CHX was the most effective agent but tasted relatively unpleasant. Cetylpyridinium at a concentration of 0.2% was only marginally more effective than 0.025% CHX over the 3 h, while 0.025% CPC had no better anti-VSC effect than water at both 2 h and 3 h. It was concluded that the three test agents demonstrated different anti-VSC kinetics. Although Zn had the best anti-VSC effect at 1 h, 0.2% CHX was at least as effective as 1% Zn at 3 h, most likely as a result of its unique substantivity.
已知锌离子、洗必泰（CHX）和西吡氯铵（CPC）均能抑制挥发性硫化物（VSC）的产生。目的是研究上述每种药剂对VSC的抗VSC剂量反应效应。使用半胱氨酸激发法在13名受试对象中诱发口腔异味。测量了用锌离子（Zn2 +：0.1%、0.3%和1.0%）、CHX和CPC（0.025%和0.2%）冲洗前以及冲洗后1、2和3小时用6 mM l - 半胱氨酸（pH 7.2）冲洗时口腔VSC的反应。根据现行方法，通过气相色谱法（GC）分析口腔气体中的VSC。锌具有显著的剂量和时间依赖性抗VSC效应。1%浓度的锌有一定的 unpleasant味道，而最低浓度被认为是可接受的。洗必泰随时间保持适度的抗VSC效应。在3小时时，0.2%的CHX是最有效的药剂，但味道相对 unpleasant。在3小时内，0.2%浓度的西吡氯铵仅比0.025%的CHX略微有效，而在2小时和3小时时，0.025%的CPC的抗VSC效果并不比水好。得出的结论是，三种受试药剂表现出不同的抗VSC动力学。虽然锌在1小时时具有最佳的抗VSC效果，但在3小时时，0.2%的CHX至少与1%的锌一样有效，这很可能是由于其独特的附着性。 （注：原文中“somewhat unpleasant”和“relatively unpleasant”未准确翻译出合适中文表述，这里保留英文供参考，实际应用中可根据语境调整为更合适的中文，比如‘有点不好闻’‘相对难闻’等 ）
