Xiang Laiqi, Rojo Rosa, Prados-Frutos Juan Carlos
Doctoral Program in Health Sciences, Faculty of Health Sciences, Rey Juan Carlos University, Avenida Atenas s/n, 28922 Alcorcón, Madrid, Spain.
Practice of Dentistry and Halitosis at Core Centro Dental, 28001 Madrid, Spain.
J Clin Med. 2021 May 23;10(11):2256. doi: 10.3390/jcm10112256.
Halitosis of oral origin is very common in the general population. Due to their antimicrobial properties, chlorhexidine-based products are widely used in the management of this condition, but these are associated with reversible side effects. In this study we evaluated the efficacy of Lacer Hali mouthrinse and toothpaste in subjects with intraoral halitosis after several applications under normal conditions of use.
In this randomized clinical trial with mouth rinse and toothpaste, single-center, double-blinded, parallel participants were assigned to an experimental group (Lacer Hali, = 20), a positive control group (Halita, = 20), and a placebo group ( = 20). The active duration of the study was 18 days. The clinical follow-up evaluations were performed at five time points (T0, T1, T2, T3, and T4). The intensity of halitosis was evaluated by organoleptic measurement and the portable gas chromatograph OralChroma. The data were analyzed using generalized mixed linear models.
Sixty patients completed the study. Lacer Hali, in comparison with Halita, did not show statistically significant differences at any time during the study except for the levels of hydrogen sulfide and total volatile sulfur compounds at 15 days, where Halita was better. Compared to the placebo treatment, Lacer Hali, was significantly more efficient, in terms of both the organoleptic evaluations at 8 days and the levels of hydrogen sulfide.
Lacer Hali is an alternative to chlorhexidine-based toothpaste and mouthwashes in the management of halitosis.
口腔源性口臭在普通人群中非常常见。基于洗必泰的产品因其抗菌特性，被广泛用于治疗这种情况，但这些产品会带来可逆的副作用。在本研究中，我们评估了Lacer Hali漱口水和牙膏在正常使用条件下多次应用后，对患有口腔口臭受试者的疗效。
在这项关于漱口水和牙膏的随机临床试验中，单中心、双盲、平行参与者被分为实验组（Lacer Hali，n = 20）、阳性对照组（Halita，n = 20）和安慰剂组（n = 20）。研究的有效时长为18天。临床随访评估在五个时间点（T0、T1、T2、T3和T4）进行。通过感官测量和便携式气相色谱仪OralChroma评估口臭的强度。使用广义混合线性模型分析数据。
60名患者完成了研究。与Halita相比，Lacer Hali在研究期间的任何时间都没有显示出统计学上的显著差异，除了在第15天时硫化氢和总挥发性硫化合物的水平，此时Halita表现更好。与安慰剂治疗相比，Lacer Hali在第8天的感官评估和硫化氢水平方面都显著更有效。
在口臭管理方面，Lacer Hali是基于洗必泰的牙膏和漱口水的替代品。
