Pole of Pneumology, ENT, and Dermatology, Institute of Experimental and Clinical Research, Université Catholique de Louvain, 1200 Brussels, Belgium.
Department of Pneumology, CHU UCL Namur, Site Mont-Godinne, 5530 Yvoir, Belgium.
Cells. 2022 Apr 13;11(8):1324. doi: 10.3390/cells11081324.
Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct respiratory diseases that share features such as the obstruction of small airways and disease flare-ups that are called exacerbations and are often caused by infections. Along the airway epithelium, immunoglobulin (Ig) A contributes to first line mucosal protection against inhaled particles and pathogens. Dimeric IgA produced by mucosal plasma cells is transported towards the apical pole of airway epithelial cells by the polymeric Ig receptor (pIgR), where it is released as secretory IgA. Secretory IgA mediates immune exclusion and promotes the clearance of pathogens from the airway surface by inhibiting their adherence to the epithelium. In this review, we summarize the current knowledge regarding alterations of the IgA/pIgR system observed in those major obstructive airway diseases and discuss their implication for disease pathogenesis.
慢性阻塞性肺疾病（COPD）、哮喘和囊性纤维化（CF）是三种不同的呼吸道疾病，它们具有共同的特征，如小气道阻塞和疾病发作（称为加重），这些通常是由感染引起的。在气道上皮细胞中，免疫球蛋白（Ig）A 有助于对吸入的颗粒和病原体进行第一道黏膜保护。黏膜浆细胞产生的二聚体 IgA 被多聚免疫球蛋白受体（pIgR）转运到气道上皮细胞的顶端极，在那里它作为分泌型 IgA 被释放。分泌型 IgA 通过抑制病原体与上皮细胞的附着来介导免疫排斥，并促进气道表面病原体的清除。在这篇综述中，我们总结了在这些主要阻塞性气道疾病中观察到的 IgA/pIgR 系统改变的最新知识，并讨论了它们对疾病发病机制的影响。
