Biederman Joseph, Mick Eric, Faraone Stephen V, Spencer Thomas, Wilens Timothy E, Wozniak Janet
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114-3139, USA.
Int J Neuropsychopharmacol. 2003 Sep;6(3):293-300. doi: 10.1017/S1461145703003547.
Despite ongoing controversy, the view that paediatric bipolar disorder is rare or non-existent has been increasingly challenged not only by case reports but also by systematic research. This research strongly suggests that paediatric bipolar disorder may not be rare but that it may be difficult to diagnose. Since children with bipolar disorder are likely to become adults with bipolar disorder, the recognition and characterization of childhood-onset bipolar disorder may help identify a meaningful developmental subtype of bipolar disorder worthy of further investigation. As recommended by Robins and Guze [American Journal of Psychiatry (1970), 126, 983-987], a psychiatric disorder may be considered a valid diagnostic entity if it can be shown to have differentiating features, evidence of familiality, specific treatment responsivity and a unique course. The goal of this article is to review our work and the extant literature within this framework to describe the evidence supporting bipolar disorder in children as a valid clinical diagnosis.
尽管仍存在争议，但小儿双相情感障碍罕见或不存在的观点不仅受到病例报告的挑战，也受到系统研究的日益质疑。这项研究有力地表明，小儿双相情感障碍可能并不罕见，而是可能难以诊断。由于双相情感障碍儿童很可能成长为患有双相情感障碍的成年人，识别和描述儿童期起病的双相情感障碍可能有助于确定一种值得进一步研究的有意义的双相情感障碍发育亚型。正如罗宾斯和古泽[《美国精神病学杂志》（1970年），126，983 - 987]所建议的，如果一种精神障碍能够显示出具有区别性特征、家族性证据、特定治疗反应性和独特病程，那么它可能被认为是一个有效的诊断实体。本文的目的是在这个框架内回顾我们的工作和现有文献，以描述支持儿童双相情感障碍作为有效临床诊断的证据。
