Henin Aude, Biederman Joseph, Mick Eric, Hirshfeld-Becker Dina R, Sachs Gary S, Wu Yelena, Yan Leslie, Ogutha Jacqueline, Nierenberg Andrew A
Pediatric Psychopharmacology Unit and Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02138, United States.
J Affect Disord. 2007 Apr;99(1-3):51-7. doi: 10.1016/j.jad.2006.09.001. Epub 2006 Oct 12.
The aim of the study was to examine antecedent childhood psychiatric disorders in adult patients with bipolar disorder.
Using structured diagnostic interviews, childhood psychiatric diagnoses of 83 referred patients with diagnosed DSM-IV bipolar disorder were compared to those of 308 adults without mood disorders.
Patients with bipolar disorder had significantly higher rates of childhood disruptive behavior disorders (ADHD, oppositional-defiant disorder, and conduct disorder), childhood anxiety disorders (separation anxiety and overanxious disorder), and enuresis, compared to patients without mood disorders. The presence of these childhood disorders was associated with an earlier age of onset of bipolar illness.
The retrospective nature of the study may have affected both the rates of disorders recalled, as well as the ages of onset of disorders. Different referral sources for bipolar and comparison participants may have also impacted findings.
Bipolar disorder in adults is frequently preceded by childhood disruptive behavior and anxiety disorders. These childhood disorders may be important markers of risk for adult bipolar disorder.
本研究旨在调查成年双相情感障碍患者童年期的先行精神障碍。
采用结构化诊断访谈，将83例已确诊为DSM-IV双相情感障碍的转诊患者的童年精神疾病诊断结果与308例无情绪障碍的成年人的诊断结果进行比较。
与无情绪障碍的患者相比，双相情感障碍患者童年期破坏性行为障碍（注意力缺陷多动障碍、对立违抗障碍和品行障碍）、童年焦虑障碍（分离焦虑和过度焦虑障碍）及遗尿症的发生率显著更高。这些童年期障碍的存在与双相情感障碍的发病年龄较早有关。
本研究的回顾性性质可能影响了所回忆的障碍发生率以及障碍的发病年龄。双相情感障碍患者和对照参与者不同的转诊来源也可能影响研究结果。
成年双相情感障碍患者常伴有童年期破坏性行为和焦虑障碍。这些童年期障碍可能是成年双相情感障碍风险的重要标志。
