Boschi A, Detry-Morel M, de Tourtchaninoff M, Guerit J M
Cliniques Universitaires St Luc, Brussels, Belgium.
Bull Soc Belge Ophtalmol. 1992;244:85-96.
Pattern electroretinogram (PERG) combined with visual evoked potential (VEP) has become increasingly useful in clinical assessment of the anterior visual pathways. In regard to the PERG dependence on ganglion cell activity, we studied monocular PERG in 36 patients (71 eyes) with intraocular hypertension (6 eyes under topical beta-blockers) and in 10 patients (18 eyes) with advanced glaucoma, to estimate the potential effect of increased IOP on ganglion cells. We recorded simultaneous VEP to evaluate the retino-cortical conduction time. Referring to normal values obtained from 19 eyes (12 subjects), we found clear-cut PERG abnormalities in 20 eyes among ocular hypertensive patients with increased IOP. They were more altered in the advanced glaucomatous group. Two or three control exams were performed in 10 patients every 6 months: however such a short-time follow-up seems too limited to define the ERG prognosis value in this pathology. Comparing the PERG with the clinical routine assessments, we discuss its place in the diagnosis and in the follow-up of patients with ocular hypertension.
图形视网膜电图（PERG）联合视觉诱发电位（VEP）在眼前视觉通路的临床评估中变得越来越有用。鉴于PERG依赖于神经节细胞的活动，我们研究了36例（71只眼）眼压升高患者（6只眼使用局部β受体阻滞剂）和10例（18只眼）晚期青光眼患者的单眼PERG，以评估眼压升高对神经节细胞的潜在影响。我们同时记录VEP以评估视网膜-皮质传导时间。参照从19只眼（12名受试者）获得的正常值，我们发现在眼压升高的高眼压患者中，20只眼存在明确的PERG异常。在晚期青光眼组中，这些异常变化更大。10例患者每6个月进行两到三次对照检查：然而，如此短时间的随访似乎过于有限，无法确定ERG在这种疾病中的预后价值。通过将PERG与临床常规评估进行比较，我们讨论了其在高眼压患者诊断和随访中的地位。
