Kerenyi Levente, Ricaurte George A, Schretlen David J, McCann Una, Varga Jozsef, Mathews William B, Ravert Hayden T, Dannals Robert F, Hilton John, Wong Dean F, Szabo Zsolt
Department of Neurology, Medical School Debrecen, Hungary.
Arch Neurol. 2003 Sep;60(9):1223-9. doi: 10.1001/archneur.60.9.1223.
Little is known about serotonin neurons in Parkinson disease (PD).
To study the serotonin system in PD with positron emission tomography, using the serotonin transporter radioligand 11CMcN5652.
We measured the density of the serotonin transporter and the density of [11C]WIN35,428-labeled dopamine transporters in the striatum of 13 adults with PD and 13 age- and sex-matched controls. To assess the effects of possible differences in blood flow or brain atrophy, we also measured regional cerebral blood flow and the size of the regions of interest for the caudate nucleus and putamen.
Patients with PD showed reductions in the specific distribution volumes of 11CMcN5652 in the caudate (P<.01) and putamen (P<.01), along with the expected reductions in striatal [11C]WIN35,428 binding (P<.01). There were no reductions in regional cerebral blood flow or the sizes of the regions of interest, mitigating against potential confounding effects of blood flow, brain atrophy, or partial volume effects. Reductions in serotonin transporter binding correlated with ratings of disease staging.
These results suggest that the density of serotonin transporters, like that of dopamine transporters, is reduced in the striatum of patients with PD and that these changes are related to disease stage.
关于帕金森病（PD）中的5-羟色胺能神经元，人们了解甚少。
使用5-羟色胺转运体放射性配体11CMcN5652，通过正电子发射断层扫描研究帕金森病中的5-羟色胺系统。
我们测量了13名成年帕金森病患者和13名年龄及性别匹配的对照者纹状体中5-羟色胺转运体的密度以及[11C]WIN35,428标记的多巴胺转运体的密度。为评估血流或脑萎缩可能存在的差异所产生的影响，我们还测量了局部脑血流以及尾状核和壳核感兴趣区域的大小。
帕金森病患者尾状核（P<0.01）和壳核（P<0.01）中11CMcN5652的特异性分布容积降低，同时纹状体中[11C]WIN35,428结合预期降低（P<0.01）。局部脑血流或感兴趣区域的大小没有降低，排除了血流、脑萎缩或部分容积效应的潜在混杂影响。5-羟色胺转运体结合的降低与疾病分期评分相关。
这些结果表明，与多巴胺转运体一样，帕金森病患者纹状体中5-羟色胺转运体的密度降低，且这些变化与疾病阶段有关。
