Hartle Alec E, Kishida Kenneth T, Sands L Paul, Batten Seth R, Barbosa Leonardo S, Bang Dan, Lohrenz Terry, White Jason P, K Sohrabi Arian, Calafiore Rebecca L, DiFeliceantonio Alexandra G, Laxton Adrian W, Tatter Stephen B, Witcher Mark R, Montague P Read, Howe W Matt
School of Neuroscience, Virginia Tech, Blacksburg, VA, USA.
Department of Biology, Wake Forest University, Winston-Salem, NC, USA.
Nat Commun. 2025 Sep 2;16(1):7958. doi: 10.1038/s41467-025-63079-w.
Dynamic changes in dopamine, noradrenaline, and serotonin release are believed to causally contribute to the neural computations that support reward-based decision making. Accordingly, changes in signaling by these systems are hypothesized to underwrite multiple cognitive and behavioral symptoms observed in many neurological disorders. Here, we characterize the release of these neurotransmitters measured concurrently in the caudate of patients with Parkinson's disease or essential tremor undergoing deep brain stimulation surgery as they played a social exchange game. We show that violations in the expected value of monetary offers are encoded by opponent patterns of dopamine and serotonin release in essential tremor, but not Parkinson's disease, patients. We also demonstrate that these changes in serotonin signaling comprise a neurochemical boundary that subsegments these two neuromotor diseases. Our combined results point to a neural signature of altered reward processing that can be used to understand the signaling deficiencies that underwrite these diseases.
多巴胺、去甲肾上腺素和血清素释放的动态变化被认为是支持基于奖励的决策的神经计算的因果因素。因此，这些系统信号的变化被假设为许多神经系统疾病中观察到的多种认知和行为症状的基础。在这里，我们描述了帕金森病或特发性震颤患者在接受深部脑刺激手术时，在玩社交交换游戏时尾状核中同时测量的这些神经递质的释放情况。我们发现，在特发性震颤患者而非帕金森病患者中，货币报价预期价值的违反由多巴胺和血清素释放的相反模式编码。我们还证明，血清素信号的这些变化构成了区分这两种神经运动疾病的神经化学边界。我们的综合结果指向了奖励处理改变的神经特征，可用于理解构成这些疾病基础的信号缺陷。
