de Angelis L
Institute of Pharmacology, University of Trieste, Italy.
Methods Find Exp Clin Pharmacol. 1992 Dec;14(10):767-71.
The chronic effects of carbamazepine administration (5, 10, 20 mg/kg i.p. daily for 14 days) on the anxiogenic response to pentylenetetrazole were studied in the light/dark aversion test. In mice, these effects were compared with those of sodium valproate (100, 200 and 300 mg/kg i.p.), a putative anxiolytic drug, and lorazepam (0.025, 0.05 and 0.10 mg/kg i.p.), a well-established anxiolytic drug. The results showed that the anxiogenic-like behavior induced by subconvulsant doses of pentylenetetrazole (15 mg/kg i.p.) was antagonized by the chronic administration of lorazepam as well as sodium valproate, a GABA agonist. In fact, the increased aversion of mice for the light compartment of the light/dark box was reduced. Carbamazepine failed to significantly alter the anxiogenic-like behavior of mice. These findings provide further evidence for the absence of anxiolytic properties of carbamazepine and for a behavioral anxiolytic profile of valproate similar to that of benzodiazepines.
在明暗回避试验中，研究了卡马西平（每天腹腔注射5、10、20mg/kg，持续14天）对戊四氮致焦虑反应的慢性影响。在小鼠中，将这些影响与假定的抗焦虑药物丙戊酸钠（腹腔注射100、200和300mg/kg）以及成熟的抗焦虑药物劳拉西泮（腹腔注射0.025、0.05和0.10mg/kg）的影响进行了比较。结果表明，亚惊厥剂量的戊四氮（腹腔注射15mg/kg）诱导的类焦虑行为被劳拉西泮以及丙戊酸钠（一种GABA激动剂）的慢性给药所拮抗。事实上，小鼠对明暗箱亮区的厌恶增加有所减少。卡马西平未能显著改变小鼠的类焦虑行为。这些发现为卡马西平缺乏抗焦虑特性以及丙戊酸具有与苯二氮䓬类相似的行为抗焦虑特征提供了进一步的证据。
