Navarro José Francisco, Dávila Guadalupe, Pedraza Carmen, Arias Jorge L
Facultad de Psicología, Universidad de Málaga, Spain.
Psicothema. 2008 Aug;20(3):460-4.
Gamma-hydroxybutyric acid (GHB) is a drug with abuse potential, popularly known as "liquid ecstasy". It is an endogenous compound of the mammalian brain which satisfies many of the criteria for consideration as a neurotransmitter or neuromodulator. In this study, the effects of acute administration of GHB (40, 80 and 120 mg/kg, ip) on anxiety, tested in the light/dark box, were examined in male mice of the OF.1 strain. Likewise, we compared the behavioural profile of GHB with that induced by mCPP (1 mg/kg, ip), a compound with known anxiogenic actions. GHB-treated mice spent notably less time in the lit area (40 and 80 mg/kg) and more time in the dark area (all doses), whereas the total number of 'rearings', transitions and latency were significantly reduced. A very similar behavioural profile was observed in mCPP-treated animals. Overall, these findings indicate that GHB exhibits anxiogenic-like properties in male mice. It is suggested that the anxiogenic effects of GHB could be related to its ability to modulate GABA and/or dopaminergic receptors.
γ-羟基丁酸（GHB）是一种具有滥用潜力的药物，俗称“液体摇头丸”。它是哺乳动物大脑中的一种内源性化合物，满足许多作为神经递质或神经调节剂的标准。在本研究中，对OF.1品系雄性小鼠进行了实验，检测腹腔注射GHB（40、80和120mg/kg）对焦虑的影响，实验在明暗箱中进行。同样，我们将GHB的行为特征与已知具有致焦虑作用的化合物mCPP（1mg/kg，腹腔注射）所诱导的行为特征进行了比较。接受GHB治疗的小鼠在亮区停留的时间显著减少（40和80mg/kg剂量组），在暗区停留的时间增加（所有剂量组），而“直立”、穿梭和潜伏期的总数显著减少。在接受mCPP治疗的动物中观察到非常相似的行为特征。总体而言，这些发现表明GHB在雄性小鼠中表现出类似致焦虑的特性。有人认为，GHB的致焦虑作用可能与其调节γ-氨基丁酸（GABA）和/或多巴胺能受体的能力有关。
