Saggese G, Baroncelli G I, Bertelloni S
Cattedra di Pediatria Preventiva e Sociale, Università degli Studi di Pisa.
Minerva Pediatr. 1992 Nov;44(11):533-49.
The past 10 years have seen a return of rickets. Clinical and/or biochemical signs of vitamin D deficiency are still found in some children and adolescents, mainly during the winter. Sunlight exposure is able to prevent vitamin D deficiency and rickets but the dramatic influence of changes in solar ultraviolet-B radiation on cutaneous vitamin D3 synthesis, related to latitude and season effects, suggest that a vitamin D supplementation may be advisable. Moreover, human milk and common foods contain low quantities of vitamin D. So, we recommend routinely 400 IU of supplementary vitamin D per day in all infants. The vitamin D requirements in low-birth-weight infants are higher than at term infants; it is recommended the use of 1000-1600 IU per day in the first months of life. Intermittent high-dose of vitamin D and vitamin D metabolites are not advisable for prophylaxis of rickets.
过去十年中佝偻病再度出现。在一些儿童和青少年中仍可发现维生素D缺乏的临床和/或生化迹象,主要在冬季。阳光照射能够预防维生素D缺乏和佝偻病,但太阳紫外线B辐射变化对皮肤维生素D3合成的显著影响,与纬度和季节效应有关,这表明补充维生素D可能是可取的。此外,母乳和常见食物中维生素D含量较低。因此,我们建议所有婴儿每天常规补充400国际单位的维生素D。低体重婴儿的维生素D需求量高于足月儿;建议在出生后的头几个月每天使用1000 - 1600国际单位。间歇性大剂量使用维生素D和维生素D代谢产物不适合用于预防佝偻病。