Segregation of HL-A27 and ankylosing spondylitis in an informative kindred.
作者信息
de Bruyère M, Nagent de Deuxchaisnes C
出版信息
Tissue Antigens. 1976 Jan;7(1):15-22. doi: 10.1111/j.1399-0039.1976.tb01024.x.
Abstract
A family with high prevalence of ankylosing spondylitis (A.S.) was investigated for the presence of HL-A27. In this family, classical A.S. occurred in five subjects and possible A.S. in two out of 64 members examined. In all seven cases, HL-A27 was present. The study of the segregation of A.S. and HL-A27 in this kindred demonstrates that more than one gene is responsible for the expression of A.S., that the homozygous state for the HL-A27 gene may lead to the occurrence of A.S., and that possibly a simple genetic explanation accounts for the simultaneous transmission of HL-A27 and A.S.
摘要
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