Xiao S H, You J Q, Guo H F, Feng J J, Sun H L, Jiao P Y, Yao M Y, Chai J J
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
Zhongguo Yao Li Xue Bao. 1992 Sep;13(5):473-7.
Mice infected with secondary cysts of Echinococcus granulosus were treated ig with mebendazole (Meb) 25 mg.kg-1.d-1 for 7-14 d. At 24 h after the last dose the endocysts in the treated mice were removed out for in vitro cultivation and exposed to [U-14C]glucose 11.1 kBq.ml-1 for 2 min, no apparent difference in radioactivity content in the cyst walls between the treated and control groups was observed. When [U-14C]glucose was given iv to the infected mice 24 h after they had been treated ig with Meb 25 mg.kg-1 or 50 mg.kg-1 daily for 14 d, the radioactivity content in the cyst wall and cyst fluid decreased significantly as compared to the corresponding control group. Nevertheless, no apparent change in the incorporation of radioactivity into the endogenous glycogen of the parasites was observed, although the glycogen in the cyst wall decreased markedly.
用细粒棘球绦虫继发性囊肿感染的小鼠，以25mg.kg-1.d-1的甲苯达唑（Meb）灌胃给药，持续7 - 14天。在末次给药后24小时，将治疗组小鼠的内囊取出进行体外培养，并暴露于11.1kBq.ml-1的[U-14C]葡萄糖中2分钟，未观察到治疗组与对照组之间囊壁放射性含量有明显差异。当感染小鼠每日以25mg.kg-1或50mg.kg-1的Meb灌胃给药14天后，在末次给药后24小时静脉注射[U-14C]葡萄糖，与相应对照组相比，囊壁和囊液中的放射性含量显著降低。然而，尽管囊壁中的糖原明显减少，但未观察到寄生虫内源性糖原放射性掺入有明显变化。
