甲状腺毒症性肌病中的终末肌内运动神经支配和运动终板
Terminal intramuscular motor innervation and motor end-plates in thyrotoxic myopathy.
作者信息
Kazakov V M
机构信息
I.P. Pavlov Medical Institute, St. Petersburg, Russia.
出版信息
Neuromuscul Disord. 1992;2(5-6):343-9. doi: 10.1016/s0960-8966(06)80005-2.
Thyrotoxic myopathy was induced in 64 mice. Examination of their muscles revealed excessive axonal branching and degenerative changes of preterminal axons. Moreover, the mean diameter of their end-plates decreased and the levels of end-plate cholinesterase appeared to be reduced. In 43 patients with thyrotoxic myopathy, increased axonal branching and degenerative changes of preterminal axons, similar to those in the experimental mice, were also seen. The possibility that excess thyroid hormone may interfere with axonal transport or neuromuscular interactions is discussed.
64只小鼠被诱导患上甲状腺毒症性肌病。对它们的肌肉检查发现有轴突发支过多以及终末前轴突的退行性改变。此外，它们终板的平均直径减小，终板胆碱酯酶水平似乎降低。在43例甲状腺毒症性肌病患者中，也观察到了与实验小鼠类似的轴突发支增加和终末前轴突的退行性改变。文中讨论了甲状腺激素过多可能干扰轴突运输或神经肌肉相互作用的可能性。
Zotero 插件